Table 4.16Definition of detection of iron deficiency

ReferenceIron dosing regimenDefinition of positive response to iron administration, ie iron- deficient
961g infusion (over 2 hours)Erythropoietic response to the iron treatment; a sustained increase in corrected reticulocyte index of one base point (ie from 1.7% to 2.7%) within 2 weeks
184500mg to 1g infusion (over 1 hour)>5% increase in Hct, 4 weeks after administration
314~1g over 8 weeksHb response ≥ 15% of baseline value
149240mg iron colloid over 2 weeksNot reported
1541.5g over 41.7 weeks
  • Reduction in weekly epoetin dose of at least 30 U/kg/week in the subsequent 12 weeks while maintaining a target Hct of 30 to 33%
  • Reduction in weekly epoetin dose of at least 60 U/kg/week in the subsequent 12 weeks while maintaining a target Hct of 30 to 33%
971g over 10 HD treatments
  • ≥ 5% increase in Hct or a decrease in epoetin dose if the Hct increased to more than 38%

HD = Haemodialysis.

From: 4, Diagnostic evaluation and assessment of anaemia

Cover of Anaemia Management in Chronic Kidney Disease
Anaemia Management in Chronic Kidney Disease: Rapid Update 2011 [Internet].
NICE Clinical Guidelines, No. 114.
National Clinical Guideline Centre (UK).
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