Figure 1. Mechanisms of TJ dysregulation that may promote tumorigenesis and metastasis.

Figure 1

Mechanisms of TJ dysregulation that may promote tumorigenesis and metastasis. TJ—associated proteins involved in controlling cellular proliferation can be divided into four different groups: transmembrane proteins, adaptor proteins, signaling proteins, and transcription factors. Altered expression levels or localization of these proteins could adversely affect other TJ components, resulting in increased intercellular permeability, loss of polarity and contact inhibition, dysregulated signaling from the TJ, and elevated expression of growth-stimulatory genes in the nucleus.

From: Tight Junction Proteins and Cancer

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