Figure 3. Coronin 1C expression levels during maturation of the grey and white matter of murine brain.

Figure 3

Coronin 1C expression levels during maturation of the grey and white matter of murine brain. Localization of Coronin 1C (Coronin 3) in sections of postnatal neocortex (A) and cerebellar sections (B, one folium is shown) of stages P1 and P20 analyzed by immunofluorescence. Coronal 6 μm sections from paraffin-embedded brains were stained with Coronin 1C specific mAb K6-444. Cp, cortical plate; L1-L6, cortical layers; wm, white matter; egc, external granule cell layer; igc, internal granule cell layer; il, intermediate layer; pcl, Purkinje cell layer. Bars, 200 μm (A), 100 μm (B). C) Distribution of Coronin 1C and myelin basic protein in total brains from postnatal day 30 analyzed by mAb K6-444 (left image) or rat monoclonal anti-MBP (right image) and visualized by DAB staining. Bst, brain stem; cb, cerebellum; co, neocortex; fi, fimbria; hc, hippocampus; ic, internal capsule; str, striatum; th, thalamus; wm, white matter of the cerebellum; pcl, Purkinje cell layer; CA3, hippocampal pyramidal CA3. Bar, 1 mm. Images according to Hasse et al (2005).27

From: The Role of Mammalian Coronins in Development and Disease

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