Figure 2. Receptor structure of IL-6 family cytokines implicated in hematopoietic stem cell regulation.

Figure 2

Receptor structure of IL-6 family cytokines implicated in hematopoietic stem cell regulation. The IL-6, LIF and IL-11 receptors are hetero-oligomeric structures containing individual cytokine-specific chains and the shared gp130 signalling chain. Members of the hematopoietin receptor family, the components of these receptors contain the characteristic extracellular domain cysteine residues (C C) and WSXWS pentapeptide motif (WS). The receptor extracellular domains also contain immunoglobulin-like domains (shaded).

From: Knockout Mouse Models of Cytokine Action in Hematopoietic Stem Cell Regulation

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