Figure 7. Endothelial perturbation creates a prothrombotic microenvironment.

Figure 7

Endothelial perturbation creates a prothrombotic microenvironment. Different stimuli induce or enhance the synthesis of the prothrombotic factors tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1), and down-regulate the production or expression of antithrombotic substances such as thrombomodulin (TM), heparan-sulfate (HS), tissue plasminogen activator activator (t-PA) and protein S (PS). This imbalance promotes the formation of fibrin and, at the same time, dampens fibrinolysis thus leading to persistent fibrin accumulation.

From: Endothelial Cell Perturbation and Disseminated Intravascular Coagulation

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