Table 1Several HSPs co-localise with protein deposits formed by tau, Aβ, huntingtin and α-synuclein in the human brain of affected individuals and modulate oligomerization and fibril formation in test tube experiments and in cell models of the respective diseases

Protein/PeptideCo-Localisation with Protein Deposits in Human BrainModulation of Aggregation Process in vitro and/or in vivoIncrease/Decrease in Affected Brain Regions
tauHSP27HSP27
HSP90HSP70, HSP90HSP70, HSP90
APPGRP78, HSP90
HSP28ABCABC, HSP27
HSP27, ABC
HSP72
Huntingtin?HSP22, HSP40, HSP70, HSP84?
SynucleinHSP40, HSP70ABC, HSP40, HSP70HSP27, ABC
ABC, HSP27, HSP110

HSP expression has also been reported to be up-or down-regulated in some of the brain regions most affected during the disease process (see text for details). Data are adapted from reference 22 and references therein.

From: The Role of Heat Shock Proteins during Neurodegeneration in Alzheimer's, Parkinson's and Huntington's Disease

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