Figure 3. Model depicting the hypothetical pathways of glucose-stimulated insulin release from insulin secretory granules in islet beta cells regulated by Syntaxin 1 (Syn1) and Syntaxin 4 (Syn4) based SNARE complexes.

Figure 3

Model depicting the hypothetical pathways of glucose-stimulated insulin release from insulin secretory granules in islet beta cells regulated by Syntaxin 1 (Syn1) and Syntaxin 4 (Syn4) based SNARE complexes. Primed granules are often found colocalized with the voltage-dependent calcium channels (VDCC) and Syn1-SNAP25 t-SNARE complexes at the plasma membrane. This pool of granules is thought to account for the initial/first phase of insulin secretion. Syntaxin 4-Munc18c complexes are also localized to the plasma membrane and mediate both first and second phase insulin secretion in islets isolated from Syntaxin 4 and Munc18c (-/+) knockout mouse models.

From: Regulation of Insulin Action and Insulin Secretion by SNARE-Mediated Vesicle Exocytosis

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