Bioavailability of Buprenorphine

Route of AdministrationBuprenorphine Bioavailability Relative to Intravenous Route of AdministrationBuprenorphine Bioavailability Relative to Intramuscular Route of AdministrationBuprenorphine Bioavailability Relative to Sublingual Solution Route of Administration
Intravenous100%
Intramuscular70%100%
Sublingual Solution49%70%100%
Sublingual Tablet29%42%50–70%

Sources: Brewster et al. 1981; Kuhlman et al. 1996; Lloyd‐Jones et al. 1980; Nath 1999; Schuh and Johanson 1999; Strain and Stitzer 1999; Weinberg et al. 1988

From: 2 Pharmacology

Cover of Clinical Guidelines for the Use of Buprenorphine in the Treatment of Opioid Addiction
Clinical Guidelines for the Use of Buprenorphine in the Treatment of Opioid Addiction.
Treatment Improvement Protocol (TIP) Series, No. 40.
Center for Substance Abuse Treatment.

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