Exhibit 3-4. Possible Side Effects of Opioid Agonist and Partial Agonist Therapy

Whole Body Effects
• Weakness, loss of energy (asthenia)
• Back pain, chills
• Fluid accumulation (edema)
• Hot flashes
• Flu syndrome and malaise
• Weight gain
Gastrointestinal Effects
• Constipation
• Dry mouth
• Nausea and vomitin
• Abdominal pain
Musculoskeletal Effects
• Joint pain (arthralgia)
• Muscle pain (myalgia)
Nervous System Effects
• Abnormal dreams
• Anxiety
• Decreased sex drive
• Depression
• Euphoria
• Headache
• Decreased sensitivity to tactile stimulation (hypesthesia)
• Insomnia
• Nervousness
• Somnolence
Respiratory Effects
• Cough
• Rhinitis
• Yawning
Cardiac Effects
• Electrocardiogram changes (possible QT prolongation with LAAM or high doses of methadone)
• Postural hypotension
• Yawning
Cardiac Effects
• Electrocardiogram changes (possible QT prolongation with LAAM or high doses of methadone)
• Postural hypotension
• Slowed heart rate (bradycardia)
Hepatic Effects
• Abnormal liver function tests
Endocrine Effects
• Hyperprolactinemia
• Absence of menstrual periods (amenorrhea)
Skin and Appendage Effects
• Sweating
• Rash
Special Sensory Effects
• Blurred vision
Urogenital Effects
• Difficult ejaculation
• Impotence

From: Chapter 3. Pharmacology of Medications Used To Treat Opioid Addiction

Cover of Medication-Assisted Treatment for Opioid Addiction in Opioid Treatment Programs
Medication-Assisted Treatment for Opioid Addiction in Opioid Treatment Programs.
Treatment Improvement Protocol (TIP) Series, No. 43.
Center for Substance Abuse Treatment.

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