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Center for Substance Abuse Treatment. Detoxification and Substance Abuse Treatment. Rockville (MD): Substance Abuse and Mental Health Services Administration (US); 2006. (Treatment Improvement Protocol (TIP) Series, No. 45.)

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Detoxification and Substance Abuse Treatment.

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Figure 4-4: Signs and Symptoms of Opioid Intoxication and Withdrawal

Opioid IntoxicationOpioid Withdrawal
Signs Signs
Bradycardia (slow pulse)Tachycardia (fast pulse)
Hypotension (low blood pressure)Hypertension (high blood pressure)
Hypothermia (low body temperature)Hyperthermia (high body temperature)
Meiosis (pinpoint pupils)Mydriasis (enlarged pupils)
Hypokinesis (slowed movement)Hyperreflexia (abnormally heightened reflexes)
Slurred speechDiaphoresis (sweating)
Head noddingPiloerection (gooseflesh)
Symptoms Increased respiratory rate
EuphoriaLacrimation (tearing), yawning
Analgesia (pain-killing effects)Rhinorrhea (runny nose)
CalmnessMuscle spasms
Abdominal cramps, nausea, vomiting, diarrhea
Bone and muscle pain

Source: Consensus Panelist Charles Dackis, M.D.


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