Figure 1. Proliferative capacity of small and large cholangiocytes purified from TC-, TLC, or control-fed rats was assessed by measurement of PCNA protein expression by western blot analysis.

Figure 1

Proliferative capacity of small and large cholangiocytes purified from TC-, TLC, or control-fed rats was assessed by measurement of PCNA protein expression by western blot analysis. Both taurocholate and taurolithocholate feeding increases proliferative activity of large cholangiocytes and induces de novo proliferation of small cholangiocytes, which are mitotically dormant in normal rat liver. The comparability of the protein used was assessed by immunoblot for β-actin. Blots (n = 5) were quantified by densitometry. *p < 0.05 vs. PCNA/β-actin protein expression of small and large cholangiocytes from rats fed control diet. Reproduced with permission from ref.35

From: Functional Heterogeneity of the Intrahepatic Biliary Epithelium

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