Figure 3. Mechanistic and structural differences between ThyA and ThyX proteins.

Figure 3

Mechanistic and structural differences between ThyA and ThyX proteins. The reactions catalyzed by ThyA and ThyX proteins are shown. Panel B corresponds to the ribbon representation of the human ThyA dimer (PDB ID: 1hvy;63 complexed with dUMP and Tomudex, a substrate analog used in cancer therapy, whereas panel D is the ribbon representation of the ThyX tetramer from Mycobacterium tuberculosis, an important human pathogen; the structure was determined in the presence of 5-bromo-dUMP and FAD; PDB ID: 2af6.47 In both representations, each monomer is highlighted in different colours and ligands are represented in the active sites. A color version of this image is available at www.landesbioscience.com/curie

From: Folate-Dependent Thymidylate-Forming Enzymes: Parallels between DNA and RNA Metabolic Enzymes and Evolutionary Implications

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