Table 1MMP expression and regulation in in vitro EMT models

Origin of the Cell LineInducer of the EMT/Comparison of Different lines with Different Invasive DegreesEMT TraitsMMP Expressed in EMT
Rat bladder carcinoma NBT-II cellsNumerous inducers(bFGF, HGF, collagens,...)Cell scattering, reorganization of E-cadherinMMP-245
Madin Darby canine kidney(MDCK)Numerous inducers (bFGF, HGF, oncogenes,...)Cell scattering, reorganization of E-cadherin, tube formation in collagen gelsMT1-MMP38,105,106
Human breast cancer cell linesComparisonLoss of E-cadherin, vimentin expression, invasivenessMT1-MMP MMP-2 activation54-57
Human breast MCF10A cellsOncogenes (v-Ha-ras and erbB2)Loss of E-cadherin, vimentin expression, invasivenessMMP-263
Human MCF10A breast cells lineWound assayE-cadherin reorganization, vimentin expression, migrationMT1-MMP66
Mouse mammary SpC-2 cellsMMP-3Loss of E-cadherin, vimentin expression, invasivenessMMP3, MMP9, MMP-1312
Mouse mammary NMuMG cellsTGF-βTransformation of extremely spindle morphology from cobblestone appereance, branching tubules in 3D collagen gelsMT1-MMP Sato, unpublished data
Mouse mammary tumour cell linesComparisonvimentin expression, invasivenessMMP-2 activation76
Rat mammary carcinoma cells linesComparisonEpithelial (E) and Mesenchymal (M) variants of the same tumour based on morphologyMMP-3, MMP-9, MMP-1378
Human bronchial cell linesComparisonLack of E-cadherin, vimentin expression, invasivenessMMP-2, MT1-MMP53,79
Human bronchial epithelial cellWound assayVimentin expression, migrationMMP-9, MMP-3, MMP-11113,114
Human prostate cancer cell linesComparisonLack of E-cadherin, vimentin expression, invasivenessMMT-MMP Williams & Thompson, unpublished, also81,82
Human cervical cell linesHuman Papillomavirus 33+ Ha-rasLack of E-cadherin, vimentin expression, invasivenessMT1-MMP, MMP-2 activation84
Squamous cell carcinoma A431snailLack of E-cadherin, vimentin expressionMMP-285

From: Matrix Metalloproteases and Epithelial-to-Mesenchymal Transition: Implications for Carcinoma Metastasis

Cover of Madame Curie Bioscience Database
Madame Curie Bioscience Database [Internet].
Austin (TX): Landes Bioscience; 2000-2013.
Copyright © 2000-2013, Landes Bioscience.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.