Figure 1. Phylogenetic tree of the coronin protein family.
Figure 1. Phylogenetic tree of the coronin protein family.

Figure 1

Phylogenetic tree of the coronin protein family. The input data consisted of an alignment comprising 420 aa in the common, conserved N-terminal region (i.e., DUF1899, WD40 and DUF1900 domains, excluding the coiled coil) from 250 species spanning the full diversity of known coronin structures. All sequences were obtained or derived from public databases and included some partial sequences from fish. Preliminary computation by the neighbor-joining algorithm of MEGA4 used pairwise maximum likelihood distances for 5000 bootstrapped alignments to approximate the given topology and branching confidence values shown as bootstrap percentages enclosed in brackets. The data were ultimately recomputed by the maximum likelihood program IQPNNI 3.2 with a gamma rate variation model to generate the displayed tree (split into two parts. A and B) with ML values of 100 at all unmarked nodes and actual ML values if less than 100. Protein names and symbols correspond to the proposed new nomenclature (see text) followed by the current, official nomenclature (HGNC), using a and b suffixes to denote the products of duplicated genes in teleosts and Xenopus laevis. A) Vertebrate coronin subfamilies 1–6 diverged around the time of emergence of the first vertebrates, based on the observed species distribution and horizontal bifurcation points. Two novel and distinct clades for coronins 8 and 9 represented by nonvertebrate animals derived from a monomeric common ancestor prior to the emergence of the placozoan Trichoplax adherens. Gene duplication events are marked by solid circles at bifurcation nodes. B) Coronin 7 originated by tandem duplication and fusion of a protozoan monomeric coronin and exhibited the broadest species ubiquity. Monomeric coronins from Alveolata, Fungi and Euglenozoa formed three distinct subfamily clades at the base of the tree, which was rooted in the single coronin from the amoeboflagellate Naegleria gruberi.

From: Molecular Phylogeny and Evolution of the Coronin Gene Family

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