Table 2Aneuploidy in PS1 knockout liver

# of cells
Chromosome #wtPS1-/-
40 (normal)6856
8001
3912
3701
2701
< 2048
% abnormal6.818.8*
Mitotic Index50%20%

Liver cells from wild type and PS-1 knockout embryos were grown in culture and their chromosomes prepared for karyotype analysis. The knockout cells grew more slowly and developed increased aneuploidy.

From: Cell Cycle and Chromosome Segregation Defects in Alzheimer's Disease

Cover of Madame Curie Bioscience Database
Madame Curie Bioscience Database [Internet].
Austin (TX): Landes Bioscience; 2000-2013.
Copyright © 2000-2013, Landes Bioscience.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.