Table 2Aneuploidy in PS1 knockout liver

# of cells
Chromosome #wtPS1-/-
40 (normal)6856
< 2048
% abnormal6.818.8*
Mitotic Index50%20%

Liver cells from wild type and PS-1 knockout embryos were grown in culture and their chromosomes prepared for karyotype analysis. The knockout cells grew more slowly and developed increased aneuploidy.

From: Cell Cycle and Chromosome Segregation Defects in Alzheimer's Disease

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