Table 4Analogs with sulfonamide aromatic modifications having a thiophene at the two position

Image ml155fu59.jpg
Pubchem CIDPubchem SIDCompound numberR1N370S AC50 (μM)Compound numberR1N370S AC50 (μM)Pubchem CIDPubchem SID
403515685267271100
Image ml155fu60.jpg
1.26119
Image ml155fu61.jpg
1.27247765185267272
4424641085267353101
Image ml155fu62.jpg
3.18120
Image ml155fu63.jpg
2.524513681092386624
4424640985267352102
Image ml155fu64.jpg
2.52121
Image ml155fu65.jpg
2.524022528685267263
2645084685267234103
Image ml155fu66.jpg
0.32122
Image ml155fu67.jpg
3.184022523885267293
4424645685267407104
Image ml155fu68.jpg
0.80123
Image ml155fu69.jpg
1.264022521385267238
4424644685267396105
Image ml155fu70.jpg
1.59124
Image ml155fu71.jpg
0.634022522085267240
4424643585267384106
Image ml155fu72.jpg
2.00125
Image ml155fu73.jpg
7.994022521885267245
4022516585267268107
Image ml155fu74.jpg
2.00126
Image ml155fu75.jpg
4.004022520285267285
4424642785267376108
Image ml155fu76.jpg
0.40127
Image ml155fu77.jpg
2.534424645485267405
4424641185267354109
Image ml155fu78.jpg
1.00128
Image ml155fu79.jpg
2.534513681292386626
2645110385267251110
Image ml155fu80.jpg
1.00129
Image ml155fu81.jpg
2.532645496885267295
4290964485267265111
Image ml155fu82.jpg
3.18130
Image ml155fu83.jpg
5.044003975385267288
1755670485267291112
Image ml155fu84.jpg
2.00131
Image ml155fu85.jpg
0.324424645585267406
2645139985267241113
Image ml155fu86.jpg
1.27132
Image ml155fu87.jpg
0.804022522585267233
4513681392386627114
Image ml155fu88.jpg
1.27133
Image ml155fu89.jpg
1.274022521585267239
2645118385267243115
Image ml155fu90.jpg
1.00134
Image ml155fu91.jpg
3.182645102385267249
4424644385267393116
Image ml155fu92.jpg
1.59135
Image ml155fu93.jpg
4.012645099285267242
2644074985267282117
Image ml155fu94.jpg
1.27136
Image ml155fu95.jpg
1.59478775685267275
4022522185267259118
Image ml155fu96.jpg
2.01137
Image ml155fu97.jpg
2.354424645885267409

From: Identification of Modulators of the N370S Mutant Form of Glucocerebrosidase as a Potential Therapy for Gaucher Disease - Chemotype 1

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

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