Table 5SAR of analogs having 2,5-substituted thiazole and thiadiazole cores

#CIDSIDNCGCStructureAC50 (μM)Rate of induction (%)
8a4690769999367961NCGC00187851-01
Image ml200fu118.jpg
0.038370
8b4690774699367991NCGC00187897-01
Image ml200fu119.jpg
0.122257
8c4690773399367986NCGC00187892-01
Image ml200fu120.jpg
0.077609
8d4690769299367967NCGC00187857-01
Image ml200fu121.jpg
0.24454
8e4690766499367932NCGC00184931-01
Image ml200fu122.jpg
0.038550
8f4690767799367966NCGC00187856-01
Image ml200fu123.jpg
0.387448
8g4690766299367931NCGC00184930-01
Image ml200fu124.jpg
0.244599
8h4690767099367965NCGC00187855-01
Image ml200fu125.jpg
inactiveinactive

From: Discovery, SAR and Biological Evaluation of Aryl-thiazol-piperidines as SMN Modulators

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

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