Medicines for Type 2 Diabetes – Benefits

Type of Medicine
 Generic NameBrand NameBenefits
Biguanides Block the liver from making sugar
MetforminGlucophage®
  • Lowers A1C by about 1 point
  • Lowers “bad” cholesterol more than other types
Sulfonylureas Raise the amount of insulin in the body
GlimepirideAmaryl®
  • Lowers A1C by about 1 point
GlipizideGlucotrol®
GlyburideDiabeta®
Glynase Prestab®
Micronase®
Meglitinides Raise the amount of insulin in the body
RepaglinidePrandin®
  • Lowers A1C by about 1 point
NateglinideStarlix®
Thiazolidinediones (TZDs) Help the body use insulin better
PioglitazoneActos®
  • Lowers A1C by about 1 point
  • Lowers triglycerides (a kind of fat in your blood) more than other types
  • Might protect kidney function
Dipeptidyl Peptidase-4 (DPP-4) Inhibitors Raise the amount of insulin in the body after a meal
SitagliptinJanuvia®
  • Lowers A1C by less than 1 point
SaxagliptinOnglyza®
Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists Raise the amount of insulin in the body
ExenatideByetta®
  • Less weight gain than other medicines
  • Less is known about how well this medicine lowers A1C compared with other medicines
LiraglutideVictoza®
Combinations
Glyburide/metformin
Metformin/pioglitazone
Metformin/sitagliptin
Metformin/saxagliptin
Metformin + GLP-1 receptor agonists
  • Metformin + GLP-1 receptor agonists may cause less weight gain than other combinations of medicines
 Metoformin + basal insulin
Metformin + premixed insulin

Some of the combinations of medicine may come in a single pill, and are shown with a “/” symbol between them. Others are taken together but are separate medicines, and are shown with a “+” symbol.

From: Medicines for Type 2 Diabetes

Cover of Comparative Effectiveness Review Summary Guides for Consumers
Comparative Effectiveness Review Summary Guides for Consumers [Internet].

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