Figure 3. Modulation of Twist requires the concerted action of a number of regulators.

Figure 3

Modulation of Twist requires the concerted action of a number of regulators. Lateral views of stage 10 embryos stained with an antibody to Twist. Anterior, left. A) Wild-type embryo shows a modulated Twist expression pattern in which each segment contains high and low domains of Twist expression. B) Embryos missing both the maternal and zygotic contributions of Notch fail to modulate Twist, resulting in uniform Twist expression. The mesoderm appears undulated due to ectopic neuroblast production in this background. C) Eve mutant embryos also fail to modulate Twist, maintaining high Twist levels throughout the mesoderm (cf7). D) Embryos lacking both slp loci express uniform low levels of Twist throughout the mesoderm (cf17).

From: Development of the Larval Somatic Musculature

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