Figure 3. Model of activation of ROS-GC1 by GCAP-1.

Figure 3

Model of activation of ROS-GC1 by GCAP-1. Decrease of cytoplasmic [Ca2+] leads first to dissociation of Ca2+ from EF-hand 3 in GCAP-1. This induces a conformational change in GCAP-1 and subsequently in ROS-GC1, which facilitates a reorientation in the DD. Formation of a correct dimer interface then increases the catalytic efficiency. Further release of Ca2+ from EF-hand 2 and 4 (EF-hand 1 is nonfunctional) might then stabilize this transition state of cGMP synthesis.

From: Target Recognition of Guanylate Cyclase by Guanylate Cyclase-Activating Proteins

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