Figure 1. Biological roles of glycodelin.

Figure 1

Biological roles of glycodelin. Sperm-egg binding: Glycodelin isoforms from amniotic and follicular fluids (glycodelin-A and glycodelin-F, respectively) inhibit sperm-egg binding in hemizona assay. The hemizonae with tightly bound spermatozoa, shown as black grains, are fixed and stained with Mayer's hematoxylin. Window of implantation: Expression of immunosuppressive glycodelin in secretory endometrial glands, demonstrated by immunohistochemical staining (dark areas in glands). Capacitation: Seminal fluid glycodelin-S helps maintaining spermatozoa in an uncapacitated state. Immunosuppression: Several immune cell functions are inhibited. Acrosome reaction: Follicular fluid glycodelin-F inhibits progesterone-induced acrosome reaction. Intact acrosomes (bright) are shown by FITC-PSA staining. Cell growth and differentiation: Glycodelin transfection to endometrial adenocarcinoma cells reduces proliferation and expression of carcinoma-associated MUC1 (black). Parts of this figure have been adapted from data in FEBS Letters,19 Journal of Biological Chemistry,35 and American Journal of Obstetrics and Gynecology.68 Abbreviations: GdA, glycodelin-A; GdF, glycodelin-F; Gd-transf., glycodelin-transfection; GdS, glycodelin-S; FITC-PSA, fluorescein isothiocyanate-Pisum sativum agglutinin; phase, phase contrast microscopy.

From: Glycodelin: A Lipocalin with Diverse Glycoform-Dependent Actions

Cover of Madame Curie Bioscience Database
Madame Curie Bioscience Database [Internet].
Austin (TX): Landes Bioscience; 2000-2013.
Copyright © 2000-2013, Landes Bioscience.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.