Figure 1. Predicted topology of CFTR protein.

Figure 1

Predicted topology of CFTR protein. The intracellular domains (R domain, NBF1 and NBF2) are known to be involved in channel gating, while the transmembrane segments (TMs), and perhaps some portion of the extracellular and intracellular loops are presumed to form the anion-conducting pore.

From: Anion Conduction by CFTR: Mechanisms and Models

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