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National Clinical Guideline Centre (UK). Unstable Angina and NSTEMI: The Early Management of Unstable Angina and Non-ST-Segment-Elevation Myocardial Infarction. London: Royal College of Physicians (UK); 2010. (NICE Clinical Guidelines, No. 94.)

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Unstable Angina and NSTEMI: The Early Management of Unstable Angina and Non-ST-Segment-Elevation Myocardial Infarction.

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Appendix FClinical questions and search strategies

Question IDSection numberQuestion wordingStudy Type Filters usedDatabases and Years
RISK3Which tables, equations, engines or scoring systems for patient-risk stratification are most predictive of death, re-infarction or other vascular events in patients with UA/NSTEMI?Systematic Reviews, RCTs, Comparative Studies and Observational StudiesMedline 1999-2009

Embase 1999-2009

Cochrane 1999-2009

Cinahl 1999-2009
ASA4What is the efficacy and safety of aspirin therapy in the medical management of patients with UA or NSTEMI compared to placebo?NoneCochrane 1995-
CLOP14What is the efficacy and safety of clopidogrel in the medical management of patients with UA or NSTEMI compared to other antiplatelets or placebo?Systematic Reviews and RCTsMedline 2003-2009

Embase 2003-2009

Cochrane 2003-2009

Cinahl 2003-2009
LMWH4What is the efficacy and safety of adding a LMWH compound to aspirin (with or without clopidogrel) in the medical management of patients with UA or NSTEMI compared to the combination of unfractionated heparin and aspirin (with or without clopidogrel)?Systematic Reviews and RCTsMedline 1999-2009

Embase 1999-2009

Cochrane 1999-2009

Cinahl 1999-2009
GLYCO14What is the efficacy and safety of adding a GPI (tirofiban, eptifibatide and abcixmab) to aspirin and heparin therapy in the medical management of patients with UA or NSTEMI compared to the combination of aspirin and LMWH?Systematic Reviews and RCTsMedline 2002-2009

Embase 2002-2009

Cochrane 2002-2009

Cinahl 2002-2009
GLYCO 24What is the efficacy and safety of adding a GPI (tirofiban, eptifibatide and abcixmab) to aspirin and heparin therapy as adjunct therapy to patients with UA/ NSTEMI undergoing PCI compared to the combination of aspirin and LMWH?Systematic Reviews and RCTsMedline 2002-2009

Embase 2002-2009

Cochrane 2002-2009

Cinahl 2002-2009
THROMB15What is the efficacy and safety of adding a Thrombin inhibitor (Bivalirudin) to the combination of aspirin, with or without a GPI, in the medical management of patients with UA or NSTEMI compared to the combination of LMWH/UFH, aspirin, with or without a GPI?Systematic Reviews and RCTsMedline 1999-2009

Embase 1999-2009

Cochrane 1999-2009

Cinahl 1999-2009
THROMB25What is the efficacy and safety of adding a Thrombin inhibitor (Hirudin and Bivalirudin) to the combination of aspirin and a GPI as adjunct therapy to patients with UA/ NSTEMI undergoing PCI compared to the combination of LMWH/UFH, aspirin, and a GPI?Systematic Reviews and RCTsMedline 1999-2009

Embase 1999-2009

Cochrane 1999-2009

Cinahl 1999-2009
PENTA15What is the efficacy and safety of adding a factor Xa inhibitor (fondaparinux) to aspirin in the medical management of patients with UA or NSTEMI compared to the combination of LMWH/ UFH and aspirin therapy?Systematic Reviews and RCTsMedline 1999-2009

Embase 1999-2009

Cochrane 1999-2009

Cinahl 1999-2009
PENTA25What is the efficacy and safety of adding a synthetic pentasaccharide (fondaparinux and enoxaparin) to aspirin as adjunct therapy to patients with UA/ NSTEMI undergoing PCI compared to the combination of LMWH/UFH and aspirin therapy?Systematic Reviews and RCTsMedline 1999-2009

Embase 1999-2009

Cochrane 1999-2009

Cinahl 1999-2009
IABP6Does the use of Intra-Aortic Balloon Pump Counterpulsation affect the outcome of patients with non-ST elevation myocardial infarction or unstable anginaSystematic Reviews, RCTs, Comparative Studies and Observational StudiesMedline 1995-2009

Embase 1995-2009

Cochrane 1995-2009

Cinahl 1995-2009
ANGIO7In adults with UA or non-ST elevation MI does early invasive investigation (i.e. angiography) with intent to assess for (and in those patients deemed suitable, to perform) revascularization improve outcomes in comparison with initial conservative treatment, with or without later angiography?Systematic Reviews, RCTs, Comparative Studies and Observational StudiesMedline 1995-2009

Embase 1995-2009

Cochrane 1995-2009

Cinahl 1995-2009
RISK2B7In patients with UA/NSTEMI who do not undergo angiography, does investigation prior to hospital discharge for myocardial ischaemia affect outcome?Systematic Reviews, RCTs, Comparative Studies and Observational StudiesMedline 1995-2009

Embase 1995-2009

Cochrane 1995-2009

Cinahl 1995-2009
RISK2A7Does pre-discharge assessment of left ventricular function predict future risk in patients with UA/NSTEMISystematic Reviews, RCTs, Comparative Studies and Observational StudiesMedline 1995-2009

Embase 1995-2009

Cochrane 1995-2009

Cinahl 1995-2009
PCI-CABG7In adults with UA or non-ST elevation MI does CABG improve outcomes in comparison with PCI?Systematic Reviews, RCTs,Medline 1995-2009

Embase 1995-2009

Cochrane 1995-2009

Cinahl 1995-2009
SPEC8Does management of inpatient care for people with unstable angina or NSTEMI by a specialist cardiology team vs non specialist team improve clinical outcomes?Systematic Reviews, RCTs, Comparative Studies and Observational StudiesMedline 1999-2009

Embase 1999-2009

Cochrane 1999-2009

Cinahl 1999-2009
PSYCH19Do early psychosocial and educational interventions, mobilisation and discharge planning (cardiac rehabilitation – Phase 1) improve emotional and physical wellbeing and long-term outcomes in people with unstable angina or NSTEMI compared to deferred (cardiac rehabilitation Phase 2)?Systematic Reviews, RCTs, Comparative Studies and Observational StudiesMedline 1999-2009

Embase 1999-2009

Cochrane 1999-2009

Cinahl 1999-2009
Copyright © 2010, National Clinical Guidelines Centre.

Apart from any fair dealing for the purposes of research or private study, criticism or review, as permitted under the Copyright, Designs and Patents Act, 1988, no part of this publication may be reproduced, stored or transmitted in any form or by any means, without the prior written permission of the publisher or, in the case of reprographic reproduction, in accordance with the terms of licences issued by the Copyright Licensing Agency in the UK. Enquiries concerning reproduction outside the terms stated here should be sent to the publisher at the UK address printed on this page.

The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore for general use.

The rights of the National Clinical Guidelines Centre to be identified as Author of this work have been asserted by them in accordance with the Copyright, Designs and Patents Act, 1988.

Bookshelf ID: NBK62734

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