Figure 4. Compartmental organization of glycoprotein maturation events in the yeast and mammalian Golgi.

Figure 4

Compartmental organization of glycoprotein maturation events in the yeast and mammalian Golgi. Yeast produce “extremely high mannose” (left) and “high mannose” (right) N-glycans. Mammals produce high mannose N-glycans bearing the mannose 6-phosphate recognition moiety on lysosomal enzymes (left) and a variety of complex N-glycans (example shown on the right). Proteolytic processing of proproteins occurs within the TGN or downstream compartments (Kex2, furin). Steps in yeast glycoprotein maturation blocked in a sec18 (NSF) mutant indicate a requirement for vesicle-mediated protein transport and suggests that each processing event occurs within a functionally distinct compartment. H indicates the site of endo H cleavage and mammalian N-glycan forms sensitive to cleavage. All yeast N-glycan forms are sensitive to endo H. man=mannose, Δman=mannose removal, P-GlcNAc=6-phospho-N-acetylglucosamine, Gal=galactose.

From: The Golgi Apparatus

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