TABLE A19-1Main Steps for the Development of Scientific Knowledge for NTD Control

YearStepReference
1980Suggestion of a single tablet of albendazole + praziquantel to treat both soil-transmitted helminthiasis and schistosomiasisRockefeller Foundation, unpublished report of Bellagio meeting 1980
1990Proposal of an integrated system for helminth control(Warren, 1990)
1992The WHO publication: “Health of School Children: Treatment of Intestinal Helminths and Schistosomiasis” suggests combined drug delivery (coadministration) of albendazole/mebendazole and praziquantelWHO/CDS/IPI/CTD 92.1
1994Development of single dose of mebendazole 500 mg(Albonico et al., 1994)
1999Study on the possibility of concurrent administration of praziquantel and albendazole(Olds et al., 1999)
2001Development of the tablet pole for the administration of praziquantel(Montresor et al., 2001)
2008Test of the safety and effectiveness of triple drug administration (ivermectin, albendazole, and praziquantel) for treatment of lymphatic filariasis, soil-transmitted helminthiasis, and schistosomiasis(Mohammed et al., 2008)

From: A19, NEGLECTED TROPICAL DISEASES: THE DEVELOPMENT OF A BRAND WITH NO COPYRIGHT. A SHIFT FROM A DISEASE-CENTERED TO A TOOL-CENTERED STRATEGIC APPROACH

Cover of The Causes and Impacts of Neglected Tropical and Zoonotic Diseases
The Causes and Impacts of Neglected Tropical and Zoonotic Diseases: Opportunities for Integrated Intervention Strategies.
Institute of Medicine (US) Forum on Microbial Threats.
Washington (DC): National Academies Press (US); 2011.
Copyright © 2011, National Academy of Sciences.

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