FIGURE 11-2. Utility of biomarkers for gene mapping.

FIGURE 11-2Utility of biomarkers for gene mapping

NOTE: The trait of interest may be too far removed from the action of individual genes to allow gene localization and identification. However, the influence of genes on the trait may be mediated through measurable biomarkers (also called endophenotypes) that are much simpler in genetic etiology and thus permit gene discovery. Note that one gene may influence different traits and that different genes may influence the same trait. In this figure, the average biomarker is influenced by 1.8 genes (with a range of 1 to 3), while the average trait is influenced by 3.2 genes (with a range of 2 to 6).

From: 11, Comments on the Utility of Social Science Surveys for the Discovery and Validation of Genes Influencing Complex Traits

Cover of Biosocial Surveys
Biosocial Surveys.
National Research Council (US) Committee on Advances in Collecting and Utilizing Biological Indicators and Genetic Information in Social Science Surveys; Weinstein M, Vaupel JW, Wachter KW, editors.
Washington (DC): National Academies Press (US); 2008.
Copyright © 2008, National Academy of Sciences.

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