Figure 9. Effect of the depletion of HERV-E.

Figure 9

Effect of the depletion of HERV-E.PTN mRNA from JEG-3 choriocarcinoma cells. (A) Northern blot analysis of total RNA from control JEG-3 cells (lane 1) and JEG-3 cells expressing a ribozyme targeted to pleiotrophin mRNA (lane 2) is shown. (B) Proliferation in vitro of control and pleiotrophin mRNA-depleted JEG-3 cells. (C) Growth curves of subcutaneous tumours in athymic nude mice. Two million control or PTN mRNA-depleted JEG-3 cells were inoculated. The data represent mean tumour size. Modified from Schulte et al.143

From: Evolutionary Aspects of Human Endogenous Retroviral Sequences (HERVs) and Disease

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