Figure 1. Estrogens induce cholangiocyte proliferation by acting on ER-α and-β subtypes.

Figure 1

Estrogens induce cholangiocyte proliferation by acting on ER-α and-β subtypes. During experimental cholestasis (BDL), estrogen (EE) serum levels are increased and this was associated with a marked enhancement of ER (mainly the β subtype) in cholangiocytes, which then start to proliferate. In hepatocytes, which do not proliferate after BDL, ER-α, the only ER expressed in hepatocytes, was down regulated.

From: Estrogen Regulation of Cholangiocyte Proliferation

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