Table 8-128Laser trabeculoplasty vs. pharmacological treatment - Clinical study characteristics

OutcomeNumber of studiesDesignLimitationsInconsistencyDirectnessOther considerations
Visual field progression0
Mean change in IOP from baseline0
Number of patients with an unacceptable IOP (follow up 2 to 48 months)45,98,1043RCT (a)Serious limitations (b)No serious inconsistencySerious indirectness (c)Serious imprecision (d)
Additional notes (e)

Studies are supplemented by data from the Cochrane systematic review Rolim 2007124.


Allocation concealment and randomisation methods are not reported in one study45 and masking of outcome assessment is not reported in any of the studies.


One study104 included 51% OHT patients.


Wide confidence interval making estimate of effect uncertain.


Although there was no statistical heterogeneity observed other differences between studies were noted in length of follow up, IOP failure criteria, laser modality, laser degrees of treatment, class of medications, mean baseline IOP and COAG population (previously untreated or treated). One study104 tested different in laser degrees of treatment against prostaglandin analogues. For the purposes of comparison the 360 degree was selected.

From: 8, Treatment of chronic open angle glaucoma

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Glaucoma: Diagnosis and Management of Chronic Open Angle Glaucoma and Ocular Hypertension.
NICE Clinical Guidelines, No. 85.
National Collaborating Centre for Acute Care (UK).
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