Table 8-110Fixed combination of prostaglandin analogues + beta-blockers vs. beta-blockers - Clinical summary of findings

OutcomeInterventionControlRelative riskAbsolute effectQuality
Mean change in IOP from baseline278289not applicableMD −1.75 (−4.00 to 0.51)Very low
Number of patients with an acceptable IOP of <18mmHg93/278 (33.5%)48/289 (16.6%)RR 2.03 (1.50 to 2.75)171 more per 1000 (from 83 more to 290 more)Very low
Number of patients experiencing a respiratory adverse event3/140 (2.1%)7/149 (4.7%)RR 0.46 (0.12 to 1.73)25 fewer per 1000 (from 41 fewer to 34 more)Low
Number of patients experiencing a cardiovascular adverse event5/140 (3.6%)2/149 (1.3%)RR 2.66 (0.52 to 13.49)22 more per 1000 (from 6 fewer to 162 more)Low
Number of patients with hyperaemia4/140 (2.9%)1/149 (0.7%)RR 4.26 (0.48 to 37.63)23 more per 1000 (from 4 fewer to 256 more)Low

From: 8, Treatment of chronic open angle glaucoma

Cover of Glaucoma
Glaucoma: Diagnosis and Management of Chronic Open Angle Glaucoma and Ocular Hypertension.
NICE Clinical Guidelines, No. 85.
National Collaborating Centre for Acute Care (UK).
Copyright © 2009, National Collaborating Centre for Acute Care.

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