ClinicalThere were no studies which reported the number of patients with visual field progression.
There were no studies which reported mean change in IOP from baseline expressed as an absolute value with standard deviation.
A separate combination of prostaglandin analogues + beta-blockers is more effective than beta-blockers alone in increasing the number of patients who reach an IOP of approx <17mmHg at 6 months follow up. (HIGH QUALITY)
Significantly more patients using a separate combination of prostaglandin analogues + beta-blockers compared to beta-blockers alone experienced hyperaemia at 6 months follow up. (MODERATE QUALITY)
EconomicSeparate combinations of prostaglandin analogues plus beta-blockers are more effective (significance not reported) but more costly than beta-blockers alone. This evidence has serious limitations and partial applicability.

From: 7, Treatment of ocular hypertension and suspected chronic open angle glaucoma

Cover of Glaucoma
Glaucoma: Diagnosis and Management of Chronic Open Angle Glaucoma and Ocular Hypertension.
NICE Clinical Guidelines, No. 85.
National Collaborating Centre for Acute Care (UK).
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