Table 7-60Fixed combination of carbonic anhydrase inhibitors + beta-blockers vs. prostaglandin analogues - Clinical study characteristics

OutcomeNumber of studiesDesignLimitationsInconsistencyDirectnessOther considerations
Visual field progression0
Mean change in IOP from baseline (follow up 6 months)1151RCTSerious limitations (a,b)No serious inconsistencyNo serious indirectnessNo serious imprecision
Number of patients with an acceptable IOP0
Number of patients experiencing a respiratory adverse event (follow up 6 months)1151RCTSerious limitations (a,b)No serious inconsistencyNo serious indirectnessSerious imprecision (c)
Number of patients with hyperaemia (follow up 6 months)1151RCTSerious limitations (a,b)No serious inconsistencyNo serious indirectnessNo serious imprecision
a

The study does not describe the method of randomisation nor whether there was allocation concealment.

b

Only assessors of IOP measurements were masked to treatment.

c

The confidence intervals are broad making the effect size imprecise.

From: 7, Treatment of ocular hypertension and suspected chronic open angle glaucoma

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Glaucoma: Diagnosis and Management of Chronic Open Angle Glaucoma and Ocular Hypertension.
NICE Clinical Guidelines, No. 85.
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