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National Collaborating Centre for Cancer (UK). Advanced Breast Cancer: Diagnosis and Treatment. Cardiff (UK): National Collaborating Centre for Cancer (UK); 2009 Feb. (NICE Clinical Guidelines, No. 81.)

Cover of Advanced Breast Cancer

Advanced Breast Cancer: Diagnosis and Treatment.

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Appendix ASearch strategies

Chapter 2. Presentation and Diagnosis Literature search summary

Topic 1. Imaging investigations for assessing disease extent & monitoring response to treatment

1. Literature search details

Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1966 -175715913/10/06
PremedlineNov 9, 20067013/10/06
Embase1980 -10896113/10/06
Cochrane LibraryIssue 3, 20062672010/10/06
Cinahl1982 -33013/10/06
BNI1994 -0013/10/06
Psychinfo1806 -0013/10/06
Amed1985 -1013/10/06
SIGLE1980 - 20050010/10/06
Web of Science (SCI & SSCI)1970 -228921214/10/06
Biomed Central1997 -63015/10/06

Total References retrieved (after de-duplication): 314

Medline search strategy (This search strategy is adapted to each database)

  1. exp Breast Neoplasms/
  2. exp “Neoplasms, Ductal, Lobular, and Medullary”/
  3. Carcinoma, Intraductal, Noninfiltrating/
  4. Carcinoma, Lobular/
  5. Carcinoma, Medullary/
  6. exp mammary neoplasms/
  7. or/1–6
  8. exp Breast/
  9. breast.tw.
  10. 8 or 9
  11. (breast adj milk).tw.
  12. (breast adj tender$).tw.
  13. 11 or 12
  14. 10 not 13
  15. exp Neoplasms/
  16. 14 and 15
  17. (breast$ adj5 (neoplasm$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or leiomyosarcoma$ or dcis or duct$ or infiltrat$ or intraduct$ or lobul$ or medullary or tubular)).mp.
  18. (mammar$ adj5 (neoplasm$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or leiomyosarcoma$ or dcis or duct$ or infiltrat$ or intraduct$ or lobul$ or medullary or tubular)).mp.
  19. Paget’s Disease, Mammary/
  20. (paget$ and (breast$ or mammary or nipple$)).tw.
  21. or/16–20
  22. 7 or 21
  23. exp Neoplasm Metastasis/
  24. ((breast$ or mammar$) adj5 (metastat$ or advance$ or second$ or recurren$ or inoperab$ or disseminat$ or incur$)).mp.
  25. (breast$ or mammar$).mp.
  26. ((stage or grade or type) adj3 (“3” or “4” or c or d or iii$ or iv$)).mp.
  27. (N1 or N2$ or N3$ or pN1$ or pN2$ or pN3$).mp.
  28. 26 or 27
  29. 25 and 28
  30. 23 or 24 or 29
  31. 22 and 30
  32. exp Radiography/
  33. (radiograph$ or xray or x-ray).mp.
  34. exp Ultrasonography/
  35. (ultrasound$ or ultrasonograph$ or sonogra$ or ultrasonic or echogra$ or echotomogra$).mp.
  36. exp Radionuclide Imaging/
  37. (radionuclide adj1 (scan$ or imaging)).tw.
  38. scintigraph$.mp.
  39. magnet$ resonance.mp.
  40. (MRI or MRI$1 or NMR$1).tw.
  41. (MR adj (imag$ or scan$)).tw.
  42. (magnet$ adj (imag$ or scan$)).tw.
  43. (magneti?ation adj3 imaging).tw.
  44. exp Tomography/
  45. exp Tomography, X-Ray Computed/
  46. PET$1.tw.
  47. PET-CT.tw.
  48. (comput$ adj1 tomogra$).tw.
  49. ((diffusion or planar or echoplanar or functional or nuclear or radionuclide or radioisotope or conventional) adj2 (scan$ or imag$ or tomogra$)).tw.
  50. (FDG-PET or FES-PET or 18F-FDG-PET or FLT-PET).mp.
  51. ((CT or CAT) adj (scan$ or imaging or examination)).tw.
  52. (PET adj (scan$ or imag$ or examination)).tw.
  53. positron emission tomograph$.mp.
  54. (bone adj3 (scan$ or imag$)).mp.
  55. or/32–55
  56. 31 and 56
  57. Liver Neoplasms/
  58. Lung Neoplasms/
  59. Bone Neoplasms/
  60. ((liver or bone or hepatic or lung) adj metastases).mp.
  61. or/58–61
  62. 22 and 56 and 62
  63. 57or 63

2. Health Economics Literature search details

Database nameNo of references foundFinish date of search
Medline13115/10/06
Premedline115/10/06
Embase23715/10/06
Cochrane Library (except NHSEED)6915/10/06
NHSEED2415/10/06
Cinahl1915/10/06
BNI015/10/06
Psychinfo115/10/06
AMED115/10/06
EconLit015/10/06
Web of Science (SCI & SSCI)9015/10/06
SIGLE015/10/06

Total References retrieved (after de-duplication): 479

3. Any further comments

Systematic reviews (2002+), RCT’s & Observational filters applied to basic search for the clinical review. SIGN Health Economics filter & SCHARR Quality of Life filter applied to basic search for the health economics review.

4. Update Search

For the update search, the same search criteria/filters were applied as initial search, date limit 2006-2008 and English language research chosen only.

Database nameNo of references foundNo of references retrievedFinish date of search
Medline3173802/04/08
Premedline (June 27, 2008)273 (already selected)30/06/08
Embase3151805/03/08
Cochrane Library (Issue 1, 2008)62221/02/08
Cinahl30419/03/08
BNI0021/02/08
Psychinfo0021/02/08
AMED1021/02/08
Web of Science (SCI & SSCI)6213828/03/08

Total References retrieved (after de-duplication): 65

Plus 1 additional reference picked up from search alerts until 1st July 2008. Final Total: 66

Topic 2. Pathological assessment and reassessment on tumour samples

1. Literature search details

Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1966 -17525418/12/06
PremedlineDec 18, 200623107/12/06
Embase1980 -13942318/12/06
Cochrane LibraryIssue 4, 20064231107/12/06
Cinahl1982 -88207/12/06
BNI1994 -0007/12/06
Psychinfo1806 – Dec Wk24007/12/06
Amed1985 -0007/12/06
SIGLE1980 - 20050019/12/06
Web of Science (SCI & SSCI)1970 -13314719/12/06
Biomed Central1997 -106019/12/06

Total References retrieved (after de-duplication): 103

Medline search strategy (This search strategy is adapted to each database)

  1. exp Breast Neoplasms/
  2. exp “Neoplasms, Ductal, Lobular, and Medullary”/
  3. Carcinoma, Intraductal, Noninfiltrating/
  4. Carcinoma, Lobular/
  5. Carcinoma, Medullary/
  6. exp mammary neoplasms/
  7. or/1–6
  8. exp Breast/
  9. breast.tw.
  10. 8 or 9
  11. (breast adj milk).tw.
  12. (breast adj tender$).tw.
  13. 11 or 12
  14. 10 not 13
  15. exp Neoplasms/
  16. 14 and 15
  17. (breast$ adj5 (neoplasm$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or leiomyosarcoma$ or dcis or duct$ or infiltrat$ or intraduct$ or lobul$ or medullary or tubular)).mp.
  18. (mammar$ adj5 (neoplasm$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or leiomyosarcoma$ or dcis or duct$ or infiltrat$ or intraduct$ or lobul$ or medullary or tubular)).mp.
  19. Paget’s Disease, Mammary/
  20. (paget$ and (breast$ or mammary or nipple$)).tw.
  21. or/16–20
  22. 7 or 21
  23. Receptor, erbB-2/
  24. Genes, erbB-2/
  25. (HER2 or HER-2 or c-erbB2 or human epidermal growth factor receptor$).mp.
  26. Receptors, Estrogen/
  27. ((oestrogen$ or estrogen or EgR or ER) adj3 (status or test$ or level$ or receptor$ or expression)).mp.
  28. ((ER adj2 positiv$) or (ER adj2 negativ$) or (EgR adj2 positiv$) or (EgR adj2 negativ$) or (oestrogen$ adj2 positiv$) or (oestrogen$ adj2 negativ$) or (estrogen adj2 negativ$) or (estrogen adj2 positiv$)).mp.
  29. Receptors, Progesterone/
  30. ((progesteron$ or progestin or PgR or PR) adj3 (status or test$ or level$ or receptor$ or expression)).mp.
  31. ((PR adj2 positiv$) or (PR adj2 negativ$) or (PgR adj2 positiv$) or (PgR adj2 negativ$) or (progesteron$ adj2 positiv$) or (progesteron$ adj2 negativ$) or (progestin adj2 negativ$) or (progestin adj2 positiv$)).mp.
  32. or/23–31
  33. 22 and 32
  34. ((change or alter or acquire$ or alter$ or conserve$ or lost or unchange$ or revert$) adj2 (status or express$)).mp.
  35. ((concordan$ or discordan$) adj5 (status or express$)).mp.
  36. 34 or 35
  37. 33 and 36
  38. ((primary or primitive) adj (tumo?r or disease or breast cancer or invasive breast cancer or focuses or diagnosis or lesion$)).mp.
  39. 33 and 38
  40. Disease Progression/
  41. (tumo?r progress$ or cancer progress$ or disease progress$ or breast cancer progress$).mp.
  42. 40 or 41
  43. 33 and 42
  44. (distant metastases or local recurren$ or minimal residual disease).mp.
  45. ((metastatic or recurrent) adj (disease$ or focuses or site$ or lesion$ or breast cancer or tissue$ or disease$ or tumo?r)).mp.
  46. 44 or 45
  47. 33 and 46
  48. 37 or 39 or 43 or 47

2. Any further comments

Systematic reviews (2002+), RCT’s & Observational filters applied to basic search for the clinical review. Not animal or laboratory studies, only clinical studies chosen. Health economics search not required.

3. Update Search

For the update search, the same search criteria/filters were applied as initial search, date limit 2006-2008 and English language research chosen only.

Database nameNo of references foundNo of references retrievedFinish date of search
Medline401305/03/08
Premedline (June 27, 2008)441 (already selected)30/06/08
Embase391305/03/08
Cochrane Library (Issue 1, 2008)63021/02/08
Cinahl55005/03/08
BNI0021/02/08
Psychinfo3021/02/08
AMED0021/02/08
Web of Science (SCI & SSCI)318605/03/08

Total References retrieved (after de-duplication): 9

Plus 1 additional reference picked up from search alerts until 1st July 2008. Final Total: 10

Chapter 3. Information and Support, Literature search summary

Topic 23a & b. In patients who have to make decisions about the management of their disease, do decision support methods produce better QoL and improve outcomes

1. Literature search details

Part a
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2001 onwards3492218/10/06
Premedline2001 onwards2018/10/06
Embase2001 onwards4713618/10/06
Cochrane Library2001 onwards5172610/11/06
Cinahl2001 onwards1042110/11/06
BNI2001 onwards4310/11/06
Psychinfo2001 onwards1524010/11/06
SIGLE2001 – 200515210/11/06
Web of Science (SCI & SSCI)2001 onwards3626010/11/06
Biomed Central2001 onwards17410/11/06

Total References retrieved (after de-duplication): 147

Part b
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2001 onwards1725821/12/06
Premedline2001 onwards1121/12/06
Embase2001 onwards601421/12/06
Cochrane Library2001 onwards45021/12/06
Cinahl2001 onwards241021/12/06
BNI2001 onwards4021/12/06
Psychinfo2001 onwards9621/12/06
SIGLE2001 – 200512021/12/06
Web of Science (SCI & SSCI)2001 onwards1591221/12/06
Biomed Central2001 onwards48021/12/06

Total References retrieved (after de-duplication): 90

Medline search strategy (This search strategy is adapted to each database)

  1. exp Breast Neoplasms/
  2. exp “Neoplasms, Ductal, Lobular, and Medullary”/
  3. exp breast/
  4. exp neoplasms/
  5. 3 and 4
  6. (breast$ adj5 (neoplasm$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or dcis or ductal or infiltrat$ or intraductal$ or lobular or medullary)).mp.
  7. exp mammary neoplasms/
  8. (mammar$ adj5 (neoplasm$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or dcis or ductal or infiltrat$ or intraductal$ or lobular or medullary)).mp.
  9. or/1–2,5–8
Part a
10.

choice behavior/

11.

decision making/

12.

exp decision support techniques/

13.

((patient$ or consumer$) adj3 (decision$ or choice or preference or participation)).tw.

14.

((personal or interpersonal or individual) adj3 (decision$ or choice or preference$ or participat$)).tw.

15.

(wom#n adj3 (decision$ or choice or preference or participation)).tw.

16.

(decision$ adj3 (aid$ or support$)).tw.

17.

exp Patient Participation/

18.

Pamphlets/

19.

exp Audiovisual Aids/

20.

(video$ or dvd$).tw.

21.

exp Internet/

22.

exp Self-Help Groups/

23.

(support$ adj2 (group$ or meet$)).tw.

24.

exp Patient Education/mt [Methods]

25.

((inform$ or support$) adj2 (tool$ or method$ or group$)).tw.

26.

or/10–25

27.

9 and 26

Part b
10.

choice behavior/

11.

decision making/

12.

exp decision support techniques/

13.

((patient$ or consumer$) adj3 (decision$ or choice or preference or participation)).tw.

14.

((personal or interpersonal or individual) adj3 (decision$ or choice or preference$ or participat$)).tw.

15.

(wom#n adj3 (decision$ or choice or preference or participation)).tw.

16.

(decision$ adj3 (aid$ or support$)).tw.

17.

or/10–16

18.

exp Patient Participation/

19.

Pamphlets/

20.

exp Audiovisual Aids/

21.

(video$ or dvd$).tw.

22.

exp Internet/

23.

exp Self-Help Groups/

24.

(support$ adj2 (group$ or meet$)).tw.

25.

exp Patient Education/mt [Methods]

26.

((inform$ or support$) adj2 (tool$ or method$ or group$)).tw. 27 or/18–26

27.

9 and 17 and 27

2. Health Economics Literature search details

Part a
Database nameNo of references foundFinish date of search
Medline12907/11/06
Premedline018/10/06
Embase17807/11/06
Cochrane Library (except NHSEED)4110/11/06
NHSEED3510/11/06
Cinahl9810/11/06
BNI010/11/06
Psychinfo1410/11/06
EconLit1410/11/06
Web of Science (SCI & SSCI)10710/11/06
SIGLE010/11/06

Total References retrieved (after de-duplication): 515

Part b
Database nameNo of references foundFinish date of search
Medline3721/12/06
Premedline321/12/06
Embase1021/12/06
Cochrane Library (except NHSEED)2921/12/06
NHSEED221/12/06
Cinahl2021/12/06
BNI021/12/06
Psychinfo021/12/06
EconLit321/12/06
Web of Science (SCI & SSCI)7421/12/06
SIGLE021/12/06

Total References retrieved (after de-duplication): 171

3. Any further comments

The following Cochrane Systematic Review was used as a basis: Decision aids for people facing health treatment or screening decisions (O’Connor et al) 2003. This review last searched for evidence in mid 2001, so this search was undertaken from 2001 onwards. The search strategy was taken from the review and criteria for executing it followed accordingly. As there was very little evidence ALL stages of breast cancer were selected. SIGN Health Economics filter & SCHARR Quality of Life filter applied to basic search for the health economics review. No date limit was placed on this search as original Cochrane Review did not cover cost-effectiveness.

4. Update Search

For the update search, the reviewer required only RCT’s and so the search was re-executed using a RCT filter, date limit 2006–2008 and English language only.

Database nameNo of references foundNo of references retrievedFinish date of search
Medline146 (182)19 (20)12/03/08 (30/06/08)
Premedline (June 27, 2008)8030/06/08
Embase1401006/05/08
Cochrane Library (Issue 2, 2008)1711407/05/08 (30/06/08)
Cinahl29613/03/08
BNI0013/03/08
Psychinfo6113/03/08
Web of Science (SCI & SSCI)2321807/05/08

Total References retrieved (after de-duplication): 35

Plus 1 additional reference picked up from search alerts until 1st July 2008. Final Total: 36

Chapter 4. Systemic Disease Literature search summary

Topic 4. The choice of first line treatment for patients with metastatic breast cancer: a) Endocrine Therapy b) Chemotherapy

1. Literature search details

Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2006 onwards304111/07/07
Premedline2006 onwards68011/07/07
Embase2006 onwards324111/07/07
Cochrane Library2006 onwards93111/07/07
Cinahl2006 onwards30111/07/07
BNI2006 onwards0011/07/07
Psychinfo2006 onwards2011/07/07
AMED2006 onwards3011/07/07
SIGLENot searched: database ended 2005Web of Science (SCI & SSCI)2006 onwards328
111/07/07Biomed Central2006 onwards22
011/07/07

Total References retrieved (after de-duplication): 2

Medline search strategy (This search strategy is adapted to each database)

  1. ((advanced or recurrent or metastatic or disseminated) adj2 breast cancer).ti,ab.
  2. ((advanced cancer or recurrent cancer or metastatic cancer or disseminated cancer or advanced carcinoma or recurrent carcinoma or metastatic carcinoma or disseminated carcinoma) adj3 breast).ti,ab.
  3. ((endocrin$ or cytotox$ or antiestrogen$ or hormon$ or antimetabolit$) adj3 (treatment or therap$ or agent$ or chemotherap$)).ti,ab.
  4. (combined modality adj (therap$ or treatment)).ti,ab.
  5. systemic therap$.ti,ab.
  6. chemotherap$.ti,ab.
  7. chemo-endocrine.ti,ab.
  8. megestrol acetate.ti.
  9. mitoxantron$.ti.
  10. mitozantron$.ti.
  11. adriamycin.ti.
  12. cyclophosphamid$.ti.
  13. fluorourac$.ti.
  14. methotrexat$.ti.
  15. 1 or 2
  16. or/3–16
  17. 17 and 18

2. Any further comments

The following Cochrane Systematic Review was used as a basis: Chemotherapy alone versus endocrine therapy alone for metastatic breast cancer (Wilcken et al) 2007. This review last searched for evidence in August 2006, so this search was undertaken from 2006 onwards. The basic search strategy was based on the focused strategy used in the review. A general exclusions filter only was used as limited data available. Health economics search not required.

3. Update Search

For the update search, the reviewer required only RCT’s and so the search was re-executed using a RCT filter, date limit 2007–2008 and English language only.

Database nameNo of references foundNo of references retrievedFinish date of search
Medline201105/03/08
Premedline (June 27, 2008)36030/06/08
Embase232205/03/08
Cochrane Library51005/03/08
Cinahl41005/03/08
BNI2005/03/08
Psychinfo4005/03/08
AMED3005/03/08
Web of Science (SCI & SSCI)308 (294)105/03/08

Total References retrieved (after de-duplication): 2

Plus 0 additional references picked up from search alerts until 1st July 2008. Final Total: 2

Topic 8. In patients with metastatic breast cancer which hormone treatments are active and in patients with metastatic breast cancer which hormone treatment is most active. Pt1 (AI’s)

1. Literature search details

Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2003 onwards2865923/01/07
Premedline2003 onwards29323/01/07
Embase2003 onwards7736424/01/07
Cochrane Library2003 onwards824825/01/07
Cinahl2003 onwards52023/01/07
BNI2003 onwards0023/01/07
Psychinfo2003 onwards2123/01/07
AMED2003 onwards4023/01/07
SIGLE2003 – 20050023/01/07
Web of Science (SCI & SSCI)2003 onwards4199825/01/07
Biomed Central2003 onwards86024/01/07

Total References retrieved (after de-duplication): 140

Medline search strategy (This search strategy is adapted to each database)

  1. exp Breast Neoplasms/
  2. exp "Neoplasms, Ductal, Lobular, and Medullary"/
  3. Carcinoma, Intraductal, Noninfiltrating/
  4. Carcinoma, Lobular/
  5. Carcinoma, Medullary/
  6. exp mammary neoplasms/
  7. or/1–6
  8. exp Breast/
  9. breast.tw.
  10. 8 or 9
  11. (breast adj milk).tw.
  12. (breast adj tender$).tw.
  13. 11 or 12
  14. 10 not 13
  15. exp Neoplasms/
  16. 14 and 15
  17. (breast$ adj5 (neoplasm$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or leiomyosarcoma$ or dcis or duct$ or infiltrat$ or intraduct$ or lobul$ or medullary or tubular)).mp.
  18. (mammar$ adj5 (neoplasm$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or leiomyosarcoma$ or dcis or duct$ or infiltrat$ or intraduct$ or lobul$ or medullary or tubular)).mp.
  19. Paget's Disease, Mammary/
  20. (paget$ and (breast$ or mammary or nipple$)).tw.
  21. or/17–20
  22. 7 or 21
  23. exp Neoplasm Metastasis/
  24. ((breast$ or mammar$) adj5 (metastat$ or advance$ or second$ or recurren$ or inoperab$ or disseminat$ or incur$)).mp.
  25. (breast$ or mammar$).mp.
  26. ((stage or grade or type) adj3 ("3" or "4" or c or d or iii$ or iv$)).mp.
  27. (N1 or N2$ or N3$ or pN1$ or pN2$ or pN3$).mp.
  28. 26 or 27
  29. 25 and 28
  30. 23 or 24 or 29
  31. 22 and 30
  32. exp Aromatase Inhibitors/
  33. (arimidex or aromasin or femara).af.
  34. Megestrol Acetate/
  35. megestrol acetat$.mp.
  36. Aminoglutethimid$.mp.
  37. or/32–38
  38. 31 and 39

2. Health Economics Literature search details

See next search for details

3. Any further comments

The following Cancer Care Ontario Practice Guideline was used as a basis: The role of aromatase inhibitors in the treatment of postmenopausal women with metastatic breast cancer (Breast Cancer Disease Site Group) 2003. This review last searched for evidence in October 2003, so this search was undertaken from 2003 onwards. No filters were placed on the results, but only trials and good quality reviews were included. The following Cochrane Review (identified during searching) formed a large part of the evidence review: Aromatase inhibitors for treatment of advanced breast cancer in postmenopausal women (Gibson et al) 2007.

4. Update Search

For the update search, the same search criteria/filters were applied as initial search, date limit 2006–2008 and English language research chosen only.

Database nameNo of references foundNo of references retrievedFinish date of search
Medline1521210/03/08
Premedline (June 27, 2008)444 (already selected)30/06/08
Embase5081310/03/08
Cochrane Library29310/03/08
Cinahl46210/03/08
BNI0010/03/08
Psychinfo2010/03/08
AMED0010/03/08
Web of Science (SCI & SSCI)2091311/03/08

Total References retrieved (after de-duplication): 25

Plus additional references picked up from search alerts until 1st July 2008 & combined with pt2 of Topic 8 search. Final Total: 56

Topic 8. In patients with metastatic breast cancer which hormone treatments are active and in patients with metastatic breast cancer which hormone treatment is most active. Pt2 (Remaining Treatments)

1. Literature search details

Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1990 onwards150625426/04/07
Premedline1990 onwards13026/04/07
Embase1990 onwards108910827/04/07
Cochrane Library1990 onwards118113727/04/07
Cinahl1990 onwards140326/04/07
AMED1990 onwards4026/04/07
BNI1990 onwards1026/04/07
Psychinfo1990 onwards7126/04/07
SIGLE1990 – 200514026/04/07
Web of Science (SCI & SSCI)1990 onwards220814001/05/07
Biomed Central1990 onwards53001/05/07

Total References retrieved (after de-duplication): 393

Medline search strategy (This search strategy is adapted to each database)

1.

exp Breast Neoplasms/

2.

exp "Neoplasms, Ductal, Lobular, and Medullary"/

3.

Carcinoma, Intraductal, Noninfiltrating/

4.

Carcinoma, Lobular/

5.

Carcinoma, Medullary/

6.

exp mammary neoplasms/

7.

or/1–6

8.

exp Breast/

9.

breast.tw.

10.

8 or 9

11.

(breast adj milk).tw.

12.

(breast adj tender$).tw.

13.

11 or 12

14.

10 not 13

15.

exp Neoplasms/

16.

14 and 15

17.

(breast$ adj5 (neoplasm$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or leiomyosarcoma$ or dcis or duct$ or infiltrat$ or intraduct$ or lobul$ or medullary or tubular)).mp.

18.

(mammar$ adj5 (neoplasm$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or leiomyosarcoma$ or dcis or duct$ or infiltrat$ or intraduct$ or lobul$ or medullary or tubular)).mp.

19.

Paget's Disease, Mammary/

20.

(paget$ and (breast$ or mammary or nipple$)).tw.

21.

or/17–20

22.

7 or 21

23.

exp Neoplasm Metastasis/

24.

((breast$ or mammar$) adj5 (metastat$ or advance$ or second$ or recurren$ or inoperab$ or disseminat$ or incur$)).mp.

25.

(breast$ or mammar$).mp.

26.

((stage or grade or type) adj3 ("3" or "4" or c or d or iii$ or iv$)).mp.

27.

(N1 or N2$ or N3$ or pN1$ or pN2$ or pN3$).mp.

28.

26 or 27

29.

25 and 28

30.

23 or 24 or 29

31.

22 and 30

32.

Tamoxifen/

33.

(Nolvadex or tamoxifen$).mp.

34.

10540-29-1.rn.

35.

(fulvestrant or faslodex).mp.

36.

ICI 182780.mp.

37.

Diethylstilbestrol/

38.

(diethylstilbestrol or stilboestrol).mp.

39.

exp Testosterone/

40.

(testosterone or striant).mp. [mp=title, original title, abstract, name of substance word, subject heading word]

41.

Dihydrotestosterone/

42.

(trilostane or modrenal or dihydrotestosterone).mp.

43.

exp Medroxyprogesterone/

44.

Megestrol Acetate/

45.

(megestrol acetat$ or megace).mp.

46.

medroxyprogesterone acetat$.mp.

48.

Goserelin/

49.

(goserelin$ or zoladex).mp.

50.

Triptorelin/

51.

(triptorelin or decapeptyl).mp. [mp=title, original title, abstract, name of substance word, subject heading word]

52.

Ovariectomy/

53.

(oopherectom$ or ovariectom$ or female castrat$).mp.

54.

irradiation menopause.mp.

55.

or/32–54

56.

31 and 55

2. Health Economics Literature search details

Database nameNo of references foundFinish date of search
Medline5601/05/07
Premedline401/05/07
Embase25401/05/07
Cochrane Library (except NHSEED)10104/05/07
NHSEED2704/05/07
Cinahl6101/05/07
Psychinfo101/05/07
Amed, BNI0 in each01/05/07
EconLit401/05/07
Web of Science (SCI & SSCI)10301/05/07
SIGLE001/05/07

Total References retrieved (after de-duplication): 499

3. Any further comments

Systematic reviews (2002+), RCT’s and Observational filters applied to basic search for the clinical review. A decision was made in consultation with the GDG that we would limit the search 1990 onwards as the amount of data available was huge and also that more recent data would be required. The health economics search was for both parts of Topic 8, with no date limit as possible limited health economics data available and the AIs reviews did not cover cost- effectiveness. Therefore, the clinical search string detailed above was added to clinical search string used for pt 1, and then a SIGN Health Economics filter & SCHARR Quality of Life filter were applied to the combined basic search.

4. Update Search

For the update search, only the RCT & Systematic Review filter was used in light of the evidence required for the initial evidence review for this topic, date limit 2006–2008 and English language research chosen only.

Database nameNo of references foundNo of references retrievedFinish date of search
Medline2081228/04/08
Premedline (June 27, 2008)314 (already selected)30/06/08
Embase5251029/04/08
Cochrane Library (Issue 2, 2008)89528/04/08
Cinahl68529/04/08
BNI1028/04/08
Psychinfo5028/04/08
AMED1028/04/08
Web of Science (SCI & SSCI)4622729/04/08

Total References retrieved (after de-duplication): 32

Plus additional references picked up from search alerts until 1st July 2008 & combined with pt1 of Topic 8 search. Final Total: 56

5. Additional Search

An additional search was undertaken to ensure that the evidence for male breast cancer patients was specifically looked at in terms of hormonal therapy as it may differ from the hormonal treatment given to female breast cancer patients. The basic search strategies for parts 1 and 2 of this topic were used as the basic search.

Database nameNo of references foundNo of references retrievedFinish date of search
Medline1996930/05/08
Premedline (July 1, 2008)2001/07/08
Embase2236730/05/08
Cochrane Library (Issue 2, 2008)41830/05/08
Cinahl37430/05/08
BNI0030/05/08
Psychinfo1030/05/08
AMED0030/05/08
Web of Science (SCI & SSCI)752130/05/08

Total References retrieved (after de-duplication): 120

Plus 0 additional references picked up from search alerts until 1st July 2008. Final Total: 120

6. Consultation Comments

Whilst analysing stakeholder consultation comments, it was noted that the original clinical question and resulting PICO table omitted certain concepts and therefore the evidence review required expanding. The following additional search string was used and added to the original patient population search string, the same criteria was used as above search (e.g. 1990 onwards, and filters):

  1. Buserelin/
  2. (buserelin or suprecur or suprefact).mp.
  3. (leuprolide or leuprorelin or lupron).mp.
  4. (goserelin$ or zoladex).mp.
  5. (triptorelin or decapeptyl).mp.
  6. (nafarelin or synarel).mp.
  7. *Gonadotropin-Releasing Hormone/
  8. lutein$ hormon$ releas$.ti,ab.
  9. (LHRH or LH-RH or LHRH-agonist$ or LH-RH-agonist$).ti,ab.
  10. gonadotrop$ releas$ hormon$.ti,ab.
  11. (GnRH or GnRHA or GnRH-agonist$ or GnRH-analog$).ti,ab.
  12. or/1–15
Database nameNo of references foundNo of references retrieved
Finish date of searchMedline12432
21/10/08Premedline (Oct 20, 2008)80
21/10/08Embase16527
21/10/08Cochrane Library (Issue 4, 2008)7332
21/10/08Cinahl130
21/10/08BNI00
21/10/08Psychinfo10
21/10/08AMED00
21/10/08Web of Science (SCI & SSCI)15952
21/10/08

Total References retrieved (after de-duplication): 79

It is advised that the additional search string is used with the original search when undertaking the update of this guideline. However, it is worth noting that all references eventually reviewed were in the original set of search results.

Topic 10a & b. Combination chemotherapy versus a. sequential chemotherapy or b. single chemotherapy (specifically for part b. eight single drugs: Docetaxel, Paclitaxel, Vinorelbine, Capecitabine, Gemcitabine, Epirubicin, Doxorubicin, Carboplatin as per PICO table)

1. Literature search details

Part a
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1966 -6783023/04/07
PremedlineApr 25, 20073023/04/07
Embase1980 -1,2472324/04/07
Cochrane LibraryIssue 2, 20071,1253525/04/07
Cinahl1982 -38223/04/07
BNI1994 -0023/04/07
Psychinfo1806 -4023/04/07
Amed1985 -1023/04/07
SIGLE1980 – 20050023/04/07
Web of Science (SCI & SSCI)1970 -9953924/04/07
Biomed Central1997 -141024/04/07

Total References retrieved (after de-duplication): 74

Part b
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1966 -8522526/09/07
PremedlineSept 25, 200788 (no filters)126/09/07
Embase1980 -12963002/10/07
Cochrane LibraryIssue 3, 20073274128/09/07
Cinahl1982 -94526/09/07
BNI1994 -1 (no filters)026/09/07
Psychinfo1806 -1 (no filters)026/09/07
Amed1985 -3 (no filters)026/09/07
SIGLE1980 – 20058026/09/07
Web of Science (SCI & SSCI)1970 -1894/1351 (1299)5503/10/07
Biomed Central1997 -76026/09/07

Total References retrieved (after de-duplication): 82

Medline search strategy (This search strategy is adapted to each database)

  1. exp Breast Neoplasms/
  2. exp "Neoplasms, Ductal, Lobular, and Medullary"/
  3. Carcinoma, Intraductal, Noninfiltrating/
  4. Carcinoma, Lobular/
  5. Carcinoma, Medullary/
  6. exp mammary neoplasms/
  7. or/1–6
  8. exp Breast/
  9. breast.tw.
  10. 8 or 9
  11. (breast adj milk).tw.
  12. (breast adj tender$).tw.
  13. 11 or 12
  14. 10 not 13
  15. exp Neoplasms/
  16. 14 and 15
  17. (breast$ adj5 (neoplasm$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or leiomyosarcoma$ or dcis or duct$ or infiltrat$ or intraduct$ or lobul$ or medullary or tubular)).mp.
  18. (mammar$ adj5 (neoplasm$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or leiomyosarcoma$ or dcis or duct$ or infiltrat$ or intraduct$ or lobul$ or medullary or tubular)).mp.
  19. Paget's Disease, Mammary/
  20. (paget$ and (breast$ or mammary or nipple$)).tw.
  21. or/16–20
  22. 7 or 21
  23. exp Neoplasm Metastasis/
  24. ((breast$ or mammar$) adj5 (metastat$ or advance$ or second$ or recurren$ or inoperab$ or disseminat$ or incur$)).mp.
  25. (breast$ or mammar$).mp.
  26. ((stage or grade or type) adj3 ("3" or "4" or c or d or iii$ or iv$)).mp.
  27. (N1 or N2$ or N3$ or pN1$ or pN2$ or pN3$).mp.
  28. 26 or 27
  29. 25 and 28
  30. 23 or 24 or 29
  31. 22 and 30
Part a
32.

(multiple-agent$ or multiple agent$ or multiple-drug$ or multiple drug$ or combination$ or combined with or concomitant or polychemotherap$ or concurrent).mp.

33.

(separate or sequential$ or consecutive or successive or following).mp.

34.

31 and 32 and 33

35.

(single-agent or single agent or single-drug or single drug or monotherap$ or monochemotherap$).mp.

36.

31 and 32 and 35

37.

34 or 36

Part b
32.

(docetaxel$ or taxotere$).mp.

33.

Paclitaxel/

34.

(paclitaxel$ or taxol$ or onxol$).mp.

35.

(vinorelbin$ or navelbin$).mp.

36.

(capecitabin$ or xeloda).mp.

37.

(gemcitabin$ or gemzar$).mp.

38.

exp Epirubicin/

39.

(epirubicin$ or ellence).mp.

40.

exp Doxorubicin/

41.

(adriamycin$ or doxorubicin$ or doxil or rubex).mp.

42.

exp Carboplatin/

43.

(carboplatin$ or paraplatin$).mp.

44.

114977-28-5.rn.

45.

33069-62-4.rn.

46.

71486-22-1.rn.

47.

154361-50-9.rn.

48.

103882-84-4.rn.

49.

56420-45-2.rn.

50.

23214-92-8.rn.

51.

41575-94-4.rn.

52.

or/1–20

53.

31 and 52

2. Any further comments

Systematic reviews (2002+), RCT’s and Observational filters applied to basic search for the clinical review. Health economics search not required.

3. Update Search

For the update search, the same search criteria/filters were applied as initial search, date limit 2006–2008 and English language research chosen only. The searches for parts a and b were executed together.

Database nameNo of references foundNo of references retrievedFinish date of search
Medline353506/05/08
Premedline (June 27, 2008)34130/06/08
Embase476507/05/08
Cochrane Library (Issue 2, 2008)212507/05/08
Cinahl76307/05/08
BNI0006/05/08
Psychinfo1006/05/08
AMED0006/05/08
Web of Science (SCI & SSCI)637807/05/08

Total References retrieved (after de-duplication): 14

0 additional references picked up from search alerts until 1st July 2008. Final Total: 14

Topic 5. The clinical effectiveness and cost effectiveness of vinorelbine for breast cancer

1. Literature search details

Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2000 onwards28310527/10/06
Premedline2000 onwards13627/10/06
Embase2000 onwards83311727/10/06
Cochrane Library2000 onwards673730/10/06
Cinahl2000 onwards22627/10/06
BNI2000 onwards0027/10/06
Psychinfo2000 onwards0027/10/06
Amed2000 onwards1127/10/06
SIGLE2000 – 20055027/10/06
Web of Science (SCI & SSCI)2000 onwards53220730/10/06
Biomed Central2000 onwards53230/10/06

Total References retrieved (after de-duplication): 254

Medline search strategy (This search strategy is adapted to each database)

  1. vinorelbine.ti,ab,nm
  2. navelbine.ti,ab
  3. 1 or 2
  4. exp Breast Neoplasms/all subheadings
  5. (breast$ adj4 (cancer$ or tum?r or malignant$)).ti,ab
  6. (breast$ adj4 (oncolog$ or carcinoma$)).ti,ab
  7. or/4–6
  8. 3 and 7

2. Health Economics Literature search details

Database nameNo of references foundFinish date of search
Medline1327/10/06
Premedline027/10/06
Embase8427/10/06
Cochrane Library (except NHSEED)1830/10/06
NHSEED530/10/06
Cinahl227/10/06
BNI, Psychinfo, Amed0 in each27/10/06
EconLit027/10/06
Web of Science (SCI & SSCI)1530/10/06
SIGLE027/10/06

Total References retrieved (after de-duplication): 106

3. Any further comments

This search constituted an update of an HTA report, details as below: The clinical effectiveness and cost- effectiveness of vinorelbine for breast cancer: systematic review and economic evaluation (Lewis et al) July 2002. This review last searched for evidence in June 2000, so this search was undertaken from 2000 onwards. The search strategy was taken from the review and criteria for executing it followed accordingly. SIGN Health Economics filter & SCHARR Quality of Life filter applied to basic search for the health economics review.

4. Update Search

For the update search, the same search criteria/filters were applied as initial search, date limit 2006–2008 and English language research chosen only.

Database nameNo of references foundNo of references retrievedFinish date of search
Medline901705/03/08
Premedline (June 27, 2008)287 (already selected) + 130/06/08
Embase2212005/03/08
Cochrane Library (Issue 1, 2008)19726/02/08
Cinahl10305/03/08
BNI0026/02/08
Psychinfo0026/02/08
AMED0026/02/08
Web of Science (SCI & SSCI)1993905/03/08

Total References retrieved (after de-duplication): 45

4 additional references picked up from search alerts until 1st July 2008. Final Total: 49

Topic 6. The clinical effectiveness and cost effectiveness of capecitabine for breast cancer

1. Literature search details

Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2002 onwards1144802/03/06
Premedline2002 onwards2102/03/06
Embase2002 onwards4406202/03/06
Cochrane Library2002 onwards311602/03/06
Cinahl2002 onwards11502/03/06
BNI2002 onwards1002/03/06
Psychinfo2002 onwards0002/03/06
Amed2002 onwards0002/03/06
SIGLE2002 – 20051102/03/06
Web of Science (SCI & SSCI)2002 onwards3187802/03/06
Biomed Central2002 onwards44002/03/06

Total References retrieved (after de-duplication): 125

Medline search strategy (This search strategy is adapted to each database)

  1. xeloda.mp
  2. 1 or 2
  3. exp Breast Neoplasms/
  4. (breast$ adj4 (cancer$ or tum?r or malignanc$)).mp
  5. (breast$ adj4 (oncolog$ or carcinoma$ or neoplas$)).mp
  6. or/4–6
  7. 3 and 7

2. Health Economics Literature search details

Database nameNo of references foundFinish date of search
Medline1015/03/06
Premedline015/03/06
Embase6115/03/06
Cochrane Library (except NHSEED)1115/03/06
NHSEED215/03/06
Cinahl415/03/06
BNI, Psychinfo, Amed0 in each15/03/06
EconLit015/03/06
Web of Science (SCI & SSCI)1115/03/06
SIGLE015/03/06

Total References retrieved (after de-duplication): 75

3. Any further comments

This search constituted an update of an HTA report, details as below: Systematic review of the clinical effectiveness and cost-effectiveness of capecitabine (Xeloda) for locally advanced and/or metastatic breast cancer (Jones et al) Feb 2004. This review last searched for evidence in May 2002, so this search was undertaken from 2002 onwards. The search strategy was taken from the review and criteria for executing it followed accordingly. Only capecitabine monotherapy or capecitabine/docetaxel were considered, all other combinations were sifted out (as per HTA exclusion criteria). SIGN Health Economics filter & SCHARR Quality of Life filter applied to basic search for the health economics review.

4. Update Search

For the update search, the same search criteria/filters were applied as initial search, date limit 2005–2008 and English language research chosen only.

Database nameNo of references foundNo of references retrievedFinish date of search
Medline994905/03/08
Premedline (June 27, 2008)7130/06/08
Embase973905/03/08
Cochrane Library (Issue 1, 2008)381427/02/08
Cinahl20905/03/08
BNI1027/02/08
Psychinfo0027/02/08
AMED0027/02/08
Web of Science (SCI & SSCI)2667905/03/08

Total References retrieved (after de-duplication): 109

Plus 4 additional references picked up from search alerts until 1st July 2008. Final Total: 113

Topic 7. The clinical effectiveness and cost effectiveness of taxanes for breast cancer

1 (a) Main literature search details

Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2000 onwards1196 (with filters)38223/02/07
Premedline2000 onwards13321/02/07
Embase2000 onwards97530823/02/07
Cochrane Library2000 onwards44016526/02/07
Cinahl2000 onwards105 (with filters)2821/02/07
BNI2000 onwards3021/02/07
Psychinfo2000 onwards3021/02/07
Amed2000 onwards8121/02/07
SIGLE2000 – 20050021/02/07
Web of Science (SCI & SSCI)2000 onwards1,34839201/03/07
Biomed Central2000 onwards92221/02/07

Total References retrieved (after de-duplication): 625

1 (b) Supplementary literature search details

Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 -661331/10/07
PremedlineOct 30, 20073031/10/07
Embase1980 -581831/10/07
Cochrane LibraryIssue 4, 200719631/10/07
Cinahl1982 -4231/10/07
BNI1994 -0031/10/07
Psychinfo1806 -0031/10/07
Amed1985 -0031/10/07
SIGLE1980 – 20050031/10/07
Web of Science (SCI & SSCI)1970 -1753431/10/07
Biomed Central1997 -16031/10/07

Total References retrieved (after de-duplication): 37

Medline search strategy

(This search strategy is adapted to each database)

  1. Paclitaxel/ [all subheadings]
  2. taxol* or taxotere*
  3. taxanes
  4. or/1–4
  5. exp Breast Neoplasms/all subheadings
  6. (breast$ adj4 (cancer$ or tum?r* or malignant$)).ti,ab
  7. (breast$ adj4 (oncolog$ or carcinoma$)).ti,ab
  8. or/6–8
  9. 5 and 9
b. Supplementary literature search details
  1. exp Breast Neoplasms/
  2. exp “Neoplasms, Ductal, Lobular, and Medullary”/
  3. Carcinoma, Intraductal, Noninfiltrating/
  4. Carcinoma, Lobular/
  5. Carcinoma, Medullary/
  6. exp mammary neoplasms/
  7. or/1–6
  8. exp Breast/
  9. breast.tw.
  10. 8 or 9
  11. (breast adj milk).tw.
  12. (breast adj tender$).tw.
  13. 11 or 12
  14. 10 not 13
  15. exp Neoplasms/
  16. 14 and 15
  17. (breast$ adj5 (neoplasm$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or leiomyosarcoma$ or dcis or duct$ or infiltrat$ or intraduct$ or lobul$ or medullary or tubular)).mp.
  18. (mammar$ adj5 (neoplasm$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or leiomyosarcoma$ or dcis or duct$ or infiltrat$ or intraduct$ or lobul$ or medullary or tubular)).mp.
  19. Paget’s Disease, Mammary/
  20. (paget$ and (breast$ or mammary or nipple$)).tw.
  21. or/17–20
  22. 7 or 21
  23. (docetaxel$ or taxotere$).mp.
  24. 114977–28–5.rn.
  25. (gemcitabin$ or gemzar).mp.
  26. 103882–84–4.rn.
  27. 23 or 24
  28. 25 or 26
  29. 22 and 27 and 28

2. Health Economics Literature search details

Database nameNo of references foundFinish date of search
Medline3521/02/07
Premedline021/02/07
Embase9623/02/07
Cochrane Library (except NHSEED)5521/02/07
NHSEED1921/02/07
Cinahl2021/02/07
BNI, Psychinfo, Amed0 in each21/02/07
EconLit221/02/07
Web of Science (SCI & SSCI)8327/02/07
SIGLE021/02/07

Total References retrieved (after de-duplication): 244

3. Any further comments

This search constituted an update of an HTA report, details as below: A rapid and systematic review of the effectiveness and cost-effectiveness of the Taxanes used in the treatment of advanced breast & ovarian cancer (Lister-Sharp et al) September 2000. This review last searched for evidence in October 2000, so this search was undertaken from 2000 onwards. The search strategy was taken from the review and criteria for executing it followed accordingly. An additional supplementary search (part b) focusing on the combination of Docetaxel and Gemcitabine only was undertaken with an RCT filter only. SIGN Health Economics filter & SCHARR Quality of Life filter applied to basic search for the health economics review.

4. Update Search

For the update search, the same search criteria/filters were applied as initial search, date limit 2006–2008 and English language research chosen only. The two part search was executed as one search.

Database nameNo of references foundNo of references retrievedFinish date of search
Medline3272025/03/08
Premedline (June 27, 2008)433 (already selected)30/06/08
Embase5981826/03/08
Cochrane Library (Issue 1, 2008)1091226/03/08
Cinahl76325/03/08
BNI0025/03/08
Psychinfo2025/03/08
AMED1025/03/08
Web of Science (SCI & SSCI)5115027/03/08

Total References retrieved (after de-duplication): 77

Plus 4 additional references picked up from search alerts until 1st July 2008. Final Total: 81

Topic 15 & 16. The appropriate chemotherapy regimes for patients with metastatic breast cancer who are HER2+, following relapse after prior anthracyclines (adjuvant or for metastatic disease) or when anthracycline is inappropriate

The management of patients with metastatic HER2+ breast cancer who a. have had no previous treatment with a biological therapy, b. have had previous treatment with a biological therapy, c. are having ongoing treatment with a biological therapy

1. Literature search details

Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1966 -5548614/07/06
PremedlineMay 22, 2006-761014/07/06
Embase1980 -8969517/07/06
Cochrane LibraryIssue 2, 2006763914/07/06
Cinahl1982 -411114/07/06
BNI1985 -9114/07/06
Psychinfo1806 -3014/07/06
AMED1985 -1014/07/06
SIGLE1980 – 20052014/07/06
Web of Science (SCI & SSCI)1970 -98313517/07/06
Biomed Central1997 -26114/07/06

Total References retrieved (after de-duplication): 255

Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1966 -861515/08/06
PremedlineMay 22, 2006-7015/08/06
Embase1980 -3281715/08/06
Cochrane LibraryIssue 3, 200654 (drug only)1715/08/06
Cinahl1982 -7515/08/06
BNI1985 -0015/08/06
Psychinfo1806 -0015/08/06
AMED1985 -0015/08/06
SIGLE1980 – 20050015/08/06
Web of Science (SCI & SSCI)1970 -1993715/08/06
Biomed Central1997 -56015/08/06

Total References retrieved (after de-duplication): 98

Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2000 onwards4754916/08/06
Premedline2000 onwards17116/08/06
Embase2000 onwards9195116/08/06
Cochrane Library2000 onwards632916/08/06
Cinahl2000 onwards39616/08/06
BNI2000 onwards8016/08/06
Psychinfo2000 onwards0016/08/06
Amed2000 onwards1016/08/06
SIGLE2000 – 20052016/08/06
Web of Science (SCI & SSCI)2000 onwards7925716/08/06
Biomed Central2000 onwards59116/08/06

Total References retrieved (after de-duplication): 115

Medline search strategy (This search strategy is adapted to each database)

  1. exp Breast Neoplasms/
  2. Carcinoma, Intraductal, Noninfiltrating/
  3. Carcinoma, Lobular/
  4. Carcinoma, Medullary/
  5. or/1–4
  6. exp Breast/
  7. breast.tw.
  8. 6 or 7
  9. (breast adj milk).tw.
  10. (breast adj tender$).tw.
  11. 9 or 10
  12. 8 not 11
  13. exp Neoplasms/
  14. 12 and 13
  15. (breast adj3 (neoplas$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or leiomyosarcoma$ or malignanc$ or dcis or duct$ or infiltrating or intraduct$ or lobul$ or medullary or tubular)).tw.
  16. (mammary adj3 (neoplas$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or leiomyosarcoma$ or malignanc$ or dcis or duct$ or infiltrating or intraduct$ or lobul$ or medullary or tubular)).tw.
  17. Paget’s Disease, Mammary/
  18. (paget$ and (breast$ or mammary or nipple$)).tw.
  19. or/14–18
  20. 5 or 19
Stage One
21.

(herceptin$ or haerceptin$).ti,ab,nm

22.

(trastuzumab or trastuzamab).ti,ab,nm

23.

21 or 22

24.

((HER-2 or HER2) adj3 (neu or positiv$ or +ive or overexpress$ or over-express$ or over express$ or amplified or amplification)).mp

25.

((bB2 or erb-B2 or erbB-2) adj3 (neu or positiv$ or +ive or overexpress$ or over-express$ or over express$ or amplified or amplification)).mp

26.

((c-erbB2 or c-erb-B2 or c-erbB-2) adj3 (neu or positiv$ or +ive or overexpress$ or over-express$ or over express$ or amplified or amplification)).mp

27.

(neu adj3 (positiv$ or +ive or overexpress$ or over-express$ or over express$ or amplified or amplification)).mp.

28.

(human epidermal growth factor adj3 (neu or positiv$ or +ive or overexpress$ or over-express$ or over express$ or amplified or amplification)).mp

29.

(epidermal growth factor adj3 (neu or positiv$ or +ive or overexpress$ or over-express$ or over express$ or amplified or amplification)).mp

30.

or/24–29

31.

23 or 30

32.

exp Anthracyclines/

33.

anthracyclin$.mp.

34.

32 or 33

35.

20 and 31 and 34

36.

20 and 23 and 30

37.

35 or 36

Stage Two
21.

lapatin$.mp

22.

tykerb.mp

23.

GW572016.mp

24.

avastin$.mp

25.

bevacizumab$.mp

26.

or/21–25

27.

20 and 26

28.

(antiVEGF or anti-VEGF).mp

29.

((rhuMAb adj2 VEGF) or rhuMAbVEGF).mp

30.

((advance$ or metastatic) adj cancer$).mp

31.

29 and 30

32.

20 and 28

33.

31 or 32

34.

27 or 33

Stage Three
35.

(herceptin or haerceptin).ti,ab,nm

36.

trastuzumab.ti,ab,nm

37.

1 or 2

38.

exp Breast Neoplasms/all subheadings

39.

(breast$ adj4 (cancer$ or tum?r or malignant$)).ti,ab

40.

(breast$ adj4 (oncolog$ or carcinoma$)).ti,ab

41.

or/4–6

42.

3 and 7

43.

Animals/

44.

Humans/

45.

9 not (9 and 10)

46.

8 not 11

2. Health Economics Literature search details

Database nameNo of references foundFinish date of search
Medline1717/07/06
Premedline117/07/06
Embase4917/07/06
Cochrane Library (except NHSEED)1017/07/06
NHSEED317/07/06
Cinahl317/07/06
BNI, Psychinfo, AMED0 in each17/07/06
EconLit017/07/06
Web of Science (SCI & SSCI)1817/07/06
SIGLE017/07/06

Total References retrieved (after de-duplication): 79

3. Any further comments

Just a general exclusions filter applied to basic search for the clinical review as very little data available. Stage Three of the search strategy constituted an update of an HTA report, details as below: Systematic review of the clinical effectiveness and cost-effectiveness of herceptin (trastuzumab) for breast cancer (Lewis et al) June 2002. This review last searched for evidence in August 2000, so this search was undertaken from 2000 onwards. The search strategy was taken from the review and criteria for executing it followed accordingly. SIGN Health Economics filter & SCHARR Quality of Life filter applied to basic search for the health economics review.

4. Update Search

For the update search, the reviewer required only RCT’s and so the search was re-executed using a RCT filter, date limit 2006–2008 and English language only. Combined search with Topics 15 and 16, results below cover all.

Database nameNo of references foundNo of references retrievedFinish date of search
Medline4253401/05/08
Premedline (June 27, 2008)422 (already selected) + 130/06/08
Embase5272501/05/08
Cochrane Library (Issue 2, 2008)832106/05/08
Cinahl621306/05/08
BNI7001/05/08
Psychinfo2001/05/08
AMED1001/05/08
Web of Science (SCI & SSCI)7399715/05/08

Total References retrieved (after de-duplication): 132

Plus 0 additional references picked up from search alerts until 1st July 2008. Final Total: 132

Chapter 5. Community and Supportive Care Literature search summary

Topic 3. The ongoing management of cancer patients in the community setting

1. Literature search details

Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1966 -8663902/05/07
PremedlinePresent file103304/05/07
Embase1980 -13961403/05/07
Cochrane LibraryIssue 2, 200725001003/05/07
Cinahl1982 -33103/05/07
BNI1994 -27203/05/07
Psychinfo1806 -15004/05/07
SIGLE1980 – 20050004/05/07
Web of Science (SCI & SSCI)1970 -1471504/05/07
Biomed Central1997 -956004/05/07

Total References retrieved (after de-duplication): 52

Medline search strategy (This search strategy is adapted to each database)

  1. exp Neoplasms/nu, dt, th
  2. antineoplas$.tw.
  3. malignant$.tw.
  4. (leucaemia$ or leukaemia$ or leukemia$).tw.
  5. Lymphom$.tw.
  6. (intraepithelial$ or carcin$ or tumo?r$ or cancer$ or sarcoma$ or neoplas$ or oncolog$ or adeno$).tw.
  7. or/1–6
  8. exp Chemotherapy, Adjuvant/
  9. exp Neoadjuvant Therapy/
  10. exp antineoplastic agents/
  11. chemotherap$.tw.
  12. polychemotherap$.tw.
  13. adjuvant therap$.tw.
  14. adjuvant treatment$.tw.
  15. neoadjuvant therap$.tw.
  16. neoadjuvant treatment$.tw.
  17. anticancer therap$.tw.
  18. anti cancer therap$.tw.
  19. anticancer treatment$.tw.
  20. anti cancer treatment$.tw.
  21. antineoplastic therap$.tw.
  22. antineoplastic treatment$.tw.
  23. anti neoplastic therap$.tw.
  24. anti neoplastic treatment$.tw.
  25. antimetabolite$.tw.
  26. or/8–25
  27. 7 and 26
  28. community.tw.
  29. exp community health services/og, st, ut
  30. Community medicine/
  31. Hospitals, Community/og, st, ut
  32. Community Health Centers/og, st, ut
  33. exp Outpatient Clinics, Hospital/og, st, ut
  34. Outpatients/
  35. (outpatient$ or out-patient$).ab,ti.
  36. exp Home Care Services/og, st, ut
  37. home.ab,ti.
  38. domiciliary.tw.
  39. exp Home Nursing/
  40. home nursing.tw.
  41. Community Health Nursing/
  42. ambulatory care/og, st, ut
  43. ambulatory.tw.
  44. Day care/og, st, ut
  45. day care.tw.
  46. outreach.ab,ti.
  47. (visiting adj3 (service$ or clinic$1 or consultation$)).tw.
  48. primary health care/og, st, ut
  49. family practice/og, st, ut
  50. general practi$.tw.
  51. port-a-cath$.tw.
  52. intravenous$ therap$.tw.
  53. exp Home Infusion Therapy/
  54. home$ chemotherap$.tw.
  55. or/28–54
  56. managed care/
  57. exp inpatients/
  58. (inpatient$ or in-patient$ or in-hospital$).ab,ti.
  59. cancer care unit$.tw.
  60. exp Cancer Care Facilities/og, st, ut [Organization & Administration, Standards, Utilization]
  61. exp Hospital Units/og, st, ut [Organization & Administration, Standards, Utilization]
  62. exp Hospitalization/st, og, ut [Standards, Organization & Administration, Utilization]
  63. exp Oncology Service, Hospital/og, st, ut [Organization & Administration, Standards, Utilization]
  64. exp Hospitals, Special/og, st, ut [Organization & Administration, Standards, Utilization]
  65. or/56–64
  66. 27 and 55
  67. 27 and 65
  68. 66 and 67

2. Health Economics Literature search details

Database nameNo of references foundFinish date of search
Medline16410/05/07
Premedline610/05/07
Embase33210/05/07
Cochrane Library (except NHSEED)36610/05/07
NHSEED29810/05/07
Cinahl5110/05/07
BNI310/05/07
Pyschinfo1610/05/07
EconLit010/05/07
Web of Science (SCI & SSCI)4210/05/07
SIGLE010/05/07

Total References retrieved (after de-duplication): 1050

3. Any further comments

RCT filter applied to basic search for the clinical review. SIGN Health Economics filter & SCHARR Quality of Life filter applied to basic search for the health economics review.

4. Update Search

For the update search, the reviewer required only RCT’s and so the search was re-executed using a RCT filter, date limit 2007–2008 and English language only.

Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2007 – 5/200826319/05/08
Premedline2007 – 5/20081441619/05/08
Embase2007 – 5/2008331119/05/08
Cochrane Library2007 – 5/2008310119/05/08
Cinahl2007 – 5/20089219/05/08
BNI2007 – 5/20084219/05/08
Psychinfo2007 – 5/20084019/05/08
Web of Science (SCI & SSCI)2007 – 5/200814019/05/08
Biomed Central2007 – 5/2008155019/05/08

Total References retrieved (after de-duplication): 24

Topic 26. What are the effective interventions used to support young families in which a parent has advanced breast cancer?

1. Literature search details

Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1966 -144437614/11/06
PremedlinePresent file843915/11/06
Embase1980 -64010601/12/06
Cochrane LibraryIssue 4, 20065958304/12/06
Cinahl1982 -30710318/12/06
BNI1994 -443218/12/06
Psychinfo1967 -48821018/12/06
SIGLE1980 - 20050022/01/07
Web of Science (SCI & SSCI)1970 -2905126/01/07
Biomed Central1997 -65024/12/06

Total References retrieved (after de-duplication): 794

Medline search strategy (This search strategy is adapted to each database)

  1. exp breast neoplasms/
  2. exp “ Neoplasms, Ductal, Lobular, and Medullary”/
  3. exp breast/
  4. exp neoplasms/
  5. 3 and 4
  6. (breast$ adj5 (neoplasm$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or dcis or ductal or infiltrat$ or intraductal$ or lobular or medullary)).mp.
  7. exp mammary neoplasms/
  8. (mammar$ adj5 (neoplasm$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or dcis or ductal or infiltrat$ or intraductal$ or lobular or medullary)).mp.
  9. or/1–2,5–8
  10. exp infant/
  11. exp child/
  12. exp adolescent/
  13. exp minors/
  14. (neonat$ or perinat$ or baby or babies or toddler$ or kid$ or child$ or schoolage$ or juvenile$ or adolescen$ or youth$ or teen$ or minor$ or boy$ or girl$).mp.
  15. exp family/
  16. exp “child of impaired parents”/
  17. (famil$ or parent$ or mother$ or father$ or son$ or daughter$).mp.
  18. or/10–17
  19. exp education/
  20. exp psychotherapy/
  21. exp cognitive therapy/
  22. exp counseling/
  23. exp self help groups/
  24. exp social support/
  25. exp hotlines/
  26. exp telephone/
  27. exp Internet/
  28. ((hot or help$ or tele$) adj line$).mp.
  29. (internet or website$).mp.
  30. (advis$ or educat$ or counsel$ or intervent$).mp.
  31. ((cognit$ or group$ or psycho$) adj (therap$ or supp$ or session$)).mp.
  32. ((self help$ or supp$ or counsel$) adj (group$ or session$)).mp.
  33. or/19–32
  34. 9 and 18 and 33

2. Health Economics Literature search details

Database nameNo of references foundFinish date of search
Medline12104/01/07
Premedline522/01/07
Embase44704/01/07
Cochrane Library (except NHSEED)10004/01/07
NHSEED1704/01/07
Cinahl16004/01/07
BNI022/01/07
Psychinfo3222/01/07
EconLit022/01/07
Web of Science (SCI & SSCI)4926/01/07
SIGLE022/01/07

Total References retrieved (after de-duplication): 779

3. Any further comments

Systematic reviews (2002+), RCT’s and Observational filters applied to basic search for the clinical review. SIGN Health Economics filter & SCHARR Quality of Life filter applied to basic search for the health economics review.

4. Update Search

For the update search, the reviewer required only RCT’s and so the search was re-executed using a RCT filter, date limit 2006–2008 and English language only.

Database nameNo of references foundNo of references retrievedFinish date of search
Medline323112/05/08
Premedline (June 27, 2008)37030/06/08
Embase239014/05/08
Cochrane Library451013/05/08
Cinahl42012/05/08
BNI18012/05/08
Psychinfo121212/05/08
AMED6112/05/08
Web of Science (SCI & SSCI)127112/05/08

Total References retrieved (after de-duplication): 5

Plus 0 additional references picked up from search alerts until 1st July 2008. Final Total: 5

Chapter 6. Management of Specific Problems: Literature search summary

Topic 21. The management of lymphoedema in breast cancer patients, a. who have completed their primary treatment and have no active disease, b. have local regional recurrent disease

1. Literature search details

Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1966 -424 (with filters)11319/06/07
PremedlineJune 18, 200733619/06/07
Embase1980 -595 (with filters)8620/06/07
Cochrane LibraryIssue 2, 20071837019/06/07
Cinahl1982 -68 (with filters)2319/06/07
BNI1994 -371419/06/07
Psychinfo1806 -21519/06/07
AMED1985 -601819/06/07
SIGLE1980 – 200510019/06/07
Web of Science (SCI & SSCI)1970 -76512920/06/07
Biomed Central1997 -46119/06/07

Total References retrieved (after de-duplication): 246

Medline search strategy (This search strategy is adapted to each database)

  1. exp Breast Neoplasms/
  2. exp “Neoplasms, Ductal, Lobular, and Medullary”/
  3. Carcinoma, Intraductal, Noninfiltrating/
  4. Carcinoma, Lobular/
  5. Carcinoma, Medullary/
  6. exp mammary neoplasms/
  7. or/1–6
  8. exp Breast/
  9. breast.tw.
  10. 8 or 9
  11. (breast adj milk).tw.
  12. (breast adj tender$).tw.
  13. 11 or 12
  14. 10 not 13
  15. exp Neoplasms/
  16. 14 and 15
  17. (breast$ adj5 (neoplasm$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or leiomyosarcoma$ or dcis or duct$ or infiltrat$ or intraduct$ or lobul$ or medullary or tubular)).mp.
  18. (mammar$ adj5 (neoplasm$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or leiomyosarcoma$ or dcis or duct$ or infiltrat$ or intraduct$ or lobul$ or medullary or tubular)).mp.
  19. Paget's Disease, Mammary/
  20. (paget$ and (breast$ or mammary or nipple$)).tw.
  21. or/17–20
  22. 7 or 21
  23. exp Mastectomy/
  24. (mastectom$ or post?mastectom$ or post-mastectom$).mp.
  25. (segmentectom$ or post?segmentectom$).mp.
  26. (lumpectom$ or post?lumpectom$).mp.
  27. (quadrectom$ or post?quadrectom$).mp.
  28. ((breast$ or mammary) adj4 surg$).mp.
  29. (breast$ adj4 (radiation or radiotherap$)).mp.
  30. or/23–29
  31. 22 or 30
  32. exp Lymphedema/
  33. lymph?ed$.mp.
  34. elephantiasis.mp.
  35. (arm$ adj4 (morbidity or swell$ or swollen or pain$ or oedema or edema)).mp.
  36. (upper limb$ adj4 (morbidity or swell$ or swollen or pain$ or oedema or edema)).mp.
  37. (lymph$ adj4 (oedema or edema)).mp.
  38. Edema/
  39. (upper limb$ or arm$).mp.
  40. 38 and 39
  41. or/32–37
  42. 40 or 41
  43. 31 and 42

2. Health Economics Literature search details

Database nameNo of references foundFinish date of search
Medline1807/06/06
Premedline307/06/06
Embase5307/06/06
Cochrane Library (except NHSEED)3007/06/06
NHSEED307/06/06
Cinahl3707/06/06
BNI007/06/06
Psychinfo407/06/06
AMED1107/06/06
EconLit007/06/06
Web of Science (SCI & SSCI)4107/06/06
SIGLE007/06/06

Total References retrieved (after de-duplication): 159

3. Any further comments

Systematic reviews (2002+), RCT and Observational filters applied to basic search for the clinical review. SIGN Health Economics filter & SCHARR Quality of Life filter applied to basic search for the health economics review.

4. Update Search

For the update search, the same search criteria/filters were applied as initial search, date limit 2006–2008 and English language research chosen only. Search was executed for both Early and Advanced BC guidelines together.

Database nameNo of references foundNo of references retrievedFinish date of search
Medline562310/04/08
Premedline (June 27, 2008)3130/06/08
Embase1151710/04/08
Cochrane Library (Issue 2, 2008)381424/04/08
Cinahl20610/04/08
BNI0010/04/08
Psychinfo10010/04/08
AMED3010/04/08
Web of Science (SCI & SSCI)2183510/04/08

Total References retrieved (after de-duplication): 50

1 additional reference picked up from search alerts until 1st July 2008. Final Total: 51

Topic 25. The role of cancer-related fatigue management in advanced breast cancer

1. Literature search details

Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1966 -80810115/05/07
PremedlineMay 14, 200731515/05/07
Embase1980 -163814616/05/07
Cochrane LibraryIssue 2, 20071984516/05/07
Cinahl1982 -2789415/05/07
BNI1994 -431815/05/07
Psychinfo1806 -1203715/05/07
Amed1985 -442115/05/07
SIGLE1980 – 20051115/05/07
Web of Science (SCI & SSCI)1970 -152321317/05/07
Biomed Central1997 -74015/05/07

Total References retrieved (after de-duplication): 345

Medline search strategy (This search strategy is adapted to each database)

  1. exp Breast Neoplasms/
  2. exp “Neoplasms, Ductal, Lobular, and Medullary”/
  3. Carcinoma, Intraductal, Noninfiltrating/
  4. Carcinoma, Lobular/
  5. Carcinoma, Medullary/
  6. exp mammary neoplasms/
  7. or/1–6
  8. exp Breast/
  9. breast.tw.
  10. 8 or 9
  11. (breast adj milk).tw.
  12. (breast adj tender$).tw.
  13. 11 or 12
  14. 10 not 13
  15. exp Neoplasms/
  16. 14 and 15
  17. (breast$ adj5 (neoplasm$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or leiomyosarcoma$ or dcis or duct$ or infiltrat$ or intraduct$ or lobul$ or medullary or tubular)).mp.
  18. (mammar$ adj5 (neoplasm$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or leiomyosarcoma$ or dcis or duct$ or infiltrat$ or intraduct$ or lobul$ or medullary or tubular)).mp.
  19. Paget's Disease, Mammary/
  20. (paget$ and (breast$ or mammary or nipple$)).tw.
  21. or/17–20
  22. 7 or 21
  23. exp Fatigue/
  24. fatigu$.ti,ab.
  25. (exhaust$ or tired$ or weary or weariness).ti,ab.
  26. (low adj energy).ti,ab.
  27. or/23–26
  28. 22 and 27

2. Health Economics Literature search details

Database nameNo of references foundFinish date of search
Medline4817/05/07
Premedline417/05/07
Embase9917/05/07
Cochrane Library (except NHSEED)3417/05/07
NHSEED217/05/07
Cinahl13917/05/07
BNI117/05/07
Psychinfo717/05/07
AMED717/05/07
EconLit017/05/07
Web of Science (SCI & SSCI)14817/05/07
SIGLE017/05/07

Total References retrieved (after de-duplication): 361

3. Any further comments

Just a general exclusions filter applied to basic search for the clinical review as very little data available. SIGN Health Economics filter & SCHARR Quality of Life filter applied to basic search for the health economics review.

4. Supplementary Literature search details

a. Non-pharmacological Interventions for Advanced Cancer Patients
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2003 -, 2005 -10327103/12/07
PremedlineNov 28, 2007198429/11/07
Embase2003 -, 2005 -7195404/12/07
Cochrane LibraryIssue 4, 200711247603/12/07
Cinahl1982 -1653329/11/07
BNI1994 -6029/11/07
Psychinfo1806 -25429/11/07
Amed1985 -34829/11/07
Web of Science (SCI & SSCI)2005 -4375404/12/07

A general exclusions filter was used in all databases. Main focus was to identify RCTs so basic Cochrane Library search was supplemented by searches in Medline and Embase (RCT filter: 2005 onwards and Systematic Review filter: 2003 onwards), and then all databases were searched without date limit and an RCT filter when appropriate.

  1. exp Neoplasms/
  2. cancer$.mp.
  3. 1 or 2
  4. exp Fatigue/
  5. (exhaust$ or tired$ or weary or weariness).ti,ab.
  6. (low adj energy).ti,ab.
  7. fatigu$.ti,ab.
  8. or/4–7
  9. 3 and 8
b. Corticosteroids for Advanced Breast Cancer Patients
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1966 -2612420/11/07
PremedlineNov 14, 20076120/11/07
Embase1980 -3211420/11/07
Cochrane LibraryIssue 4, 2007881320/11/07
Cinahl1982 -30620/11/07
BNI1994 -2120/11/07
Psychinfo1806 -19120/11/07
Amed1985 -13320/11/07
SIGLE1980 – 20050020/11/07
Web of Science (SCI & SSCI)1970 -2103220/11/07
Biomed Central1997 -32020/11/07

Just a general exclusions filter applied to basic search for the clinical review as very little data available.

  1. exp Neoplasms/
  2. cancer$.mp.
  3. fatigu$.mp.
  4. 1 or 2
  5. 3 and 4
  6. exp Adrenal Cortex Hormones/
  7. exp Megestrol Acetate/
  8. 51154–23-5.rn.
  9. (megestrol adj acetat$).mp.
  10. megace.mp.
  11. 50-24-8.rn.
  12. (methylprednisolon$ or prednisolon$).mp.
  13. 53-03-2.rn.
  14. (prednison$ or sterapred$).mp.
  15. 50-02-2.rn.
  16. (dexamethason$ or decadron$).mp.
  17. corticosteroid$.mp.
  18. or/6–20
  19. 5 and 21
  20. (terminal$ adj (cancer$ or ill$ or care)).ti,ab.
  21. (palliativ$ adj (cancer$ or ill$ or care)).ti,ab.
  22. 23 or 24
  23. 4 and 21 and 25
  24. 22 or 26

5. Update Search

a. Non-pharmacological Interventions for Advanced Cancer Patients

For the update search, the reviewer required only RCT’s and so the search was re-executed using a RCT filter, date limit 2007–2008 and English language only.

Database nameNo of references foundNo of references retrievedFinish date of search
Medline53514/05/08
Premedline (June 27, 2008)322 (already selected)30/06/08
Embase119614/05/08
Cochrane Library (Issue 2, 2008)49714/05/08
Cinahl28815/05/08
BNI1014/05/08
Psychinfo3114/05/08
AMED2114/05/08
Web of Science (SCI & SSCI)2231415/05/08
b. Corticosteroids for Advanced Cancer Patients

For the update search, the reviewer required only RCT’s and so the search was re-executed using a RCT filter, date limit 2007–2008 and English language only.

Database nameNo of references foundNo of references retrievedFinish date of search
Medline25515/05/08
Premedline (June 27, 2008)0030/06/08
Embase60315/05/08
Cochrane Library (Issue 2, 2008)5415/05/08
Cinahl5215/05/08
BNI0015/05/08
Psychinfo2115/05/08
AMED3015/05/08
Web of Science (SCI & SSCI)33415/05/08

Total References retrieved (after de-duplication) for parts a & b together: 35

Plus 1 additional reference. Final Total: 36

c. CRF Treatment in Advanced Breast Cancer Patients

For the update search, the search was executed as originally, date limit 2007–2008 and English language only.

Database nameNo of references foundNo of references retrievedFinish date of search
Medline1291916/05/08
Premedline (June 27, 2008)101 (already selected)30/06/08
Embase3041716/05/08
Cochrane Library (Issue 2, 2008)30916/05/08
Cinahl58616/05/08
BNI15216/05/08
Psychinfo38616/05/08
AMED13016/05/08
Web of Science (SCI & SSCI)3253216/05/08

Total References retrieved (after de-duplication): 45

Topic 22. The management of patients with uncontrolled local disease in the presence of metastases or following primary treatment

1. Literature search details

Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1966 -8068905/02/07
PremedlineFeb 5, 200752005/02/07
Embase1980 -14437507/02/07
Cochrane LibraryIssue 1, 200787606/02/07
Cinahl1982 -776606/02/07
BNI1994 -594705/02/07
Psychinfo1806 -6105/02/07
AMED1985 -14705/02/07
SIGLE1980 – 20053205/02/07
Web of Science (SCI & SSCI)1970 -11484706/02/07
Biomed Central1997 -10005/02/07
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1966 -5268814/02/07
PremedlinePresent file27514/02/07
Embase1980 -3374316/02/07
Cochrane LibraryIssue 1, 200723115/02/07
Cinahl1982 -32514/02/07
BNI1994 -1014/02/07
Psychinfo1806 -3014/02/07
AMED1985 -4114/02/07
SIGLE1980 – 20050015/02/07
Web of Science (SCI & SSCI)1970 -3619415/02/07
Biomed Central1997 -27215/02/07

Total References retrieved (after de-duplication): 359

Medline search strategy (This search strategy is adapted to each database)

  1. exp Breast Neoplasms/
  2. exp “Neoplasms, Ductal, Lobular, and Medullary”/
  3. Carcinoma, Intraductal, Noninfiltrating/
  4. Carcinoma, Lobular/
  5. Carcinoma, Medullary/
  6. exp mammary neoplasms/
  7. or/1–6
  8. exp Breast/
  9. breast.tw.
  10. 8 or 9
  11. (breast adj milk).tw.
  12. (breast adj tender$).tw.
  13. 11 or 12
  14. 10 not 13
  15. exp Neoplasms/
  16. 14 and 15
  17. (breast$ adj5 (neoplasm$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or leiomyosarcoma$ or dcis or duct$ or infiltrat$ or intraduct$ or lobul$ or medullary or tubular)).mp.
  18. (mammar$ adj5 (neoplasm$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or leiomyosarcoma$ or dcis or duct$ or infiltrat$ or intraduct$ or lobul$ or medullary or tubular)).mp.
  19. Paget's Disease, Mammary/
  20. (paget$ and (breast$ or mammary or nipple$)).tw.
  21. or/17–20
  22. 7 or 21
  23. exp Neoplasm Metastasis/
  24. ((breast$ or mammar$) adj5 (metastat$ or advance$ or second$ or recurren$ or inoperab$ or disseminat$ or incur$)).mp.
  25. (breast$ or mammar$).mp.
  26. ((stage or grade or type) adj3 (“3” or “4” or c or d or iii$ or iv$)).mp.
  27. (N1 or N2$ or N3$ or pN1$ or pN2$ or pN3$).mp.
  28. 26 or 27
  29. 25 and 28
  30. 23 or 24 or 29
  31. 22 and 30
  32. Necrosis/
  33. exp Skin Care/
  34. Skin Neoplasms/sc [Secondary]
  35. ((skin or cutaneous) adj4 (metast$ or involv$ or tumour$ or tumor$ or lesion$ or wound$ or carcinoma$)).mp.
  36. (fungat$ adj10 (lesion$ or wound$ or tumor$ or tumour$ or cancer$ or breast cancer$ or carcinoma$ or mass or neoplasm$)).mp.
  37. (ulcer$ adj2 (carcinoma$ or lesion$ or wound$ or tumor$ or tumour$ or cancer$ or breast cancer$ or mass or neoplasm$)).mp.
  38. cancer$ wound$.mp.
  39. uncontroll$ local disease$.mp.
  40. (mucinous$ adj2 (breast cancer$ or breast carcinoma$ or breast tumour$ or breast tumor$)).mp.
  41. or/32–40
  42. 31 and 41
  43. Adenocarcinoma, Mucinous/
  44. exp Breast Neoplasms/ or exp Breast/
  45. 43 and 44
  46. 30 and 45
  47. 42 or 46
  48. *Phosphorylcholine/
  49. *Debridement/
  50. maggot$.ti,ab.
  51. (larva$ adj (therap$ or treatment$)).ti,ab.
  52. or/48–54
  53. 31 and 55
  54. 47 or 56
  55. 36 or 57

Extra search done (results in second results box above)

59.

((locally advanced or locally recurrent) adj (breast cancer or breast carcinoma)).mp.

60.

((chest wall or thoracic wall) adj3 (reconstruct$ or resect$)).mp.

61.

(palliative adj2 resect$).mp.

62.

[60 or 61 (and then put with general breast cancer search)] or 59

2. Any further comments

Systematic reviews (2002+), RCT’s and Observational filters applied to basic search for the clinical review. Health economics search not required.

3. Update Search

For the update search, the reviewer required only RCT’s and so the search was re-executed using a RCT filter, date limit 2006–2008 and English language only.

Database nameNo of references foundNo of references retrievedFinish date of search
Medline214909/05/08
Premedline (June 27, 2008)10030/06/08
Embase313409/05/08
Cochrane Library117109/05/08
Cinahl21212/05/08
BNI13909/05/08
Psychinfo0009/05/08
AMED4209/05/08
Web of Science (SCI & SSCI)308212/05/08

Total References retrieved (after de-duplication): 18

Plus 0 additional references picked up from search alerts until 1st July 2008. Final Total: 18

Topic 18. The management of metastatic bone disease (inc. bisphosphonates, samarium, radiotherapy, surgery and rehabilitation)

1. Literature search details

Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1966 -147755319/09/06
PremedlinePresent file661820/09/06
Embase1980 -129338121/09/06
Cochrane LibraryIssue 3, 20062596403/10/06
Cinahl1982 -1152503/10/06
BNI1994 -73603/10/06
Psychinfo1806 -68203/10/06
SIGLE1980 – 20059503/10/06
Web of Science (SCI & SSCI)1970 -1427409/10/06
Biomed Central1997 -1311410/10/06

Total References retrieved (after de-duplication): 917

Medline search strategy (This search strategy is adapted to each database)

  1. exp Breast Neoplasms/
  2. exp “Neoplasms, Ductal, Lobular, and Medullary”/
  3. exp breast/
  4. exp neoplasms/
  5. 3 and 4
  6. (breast$ adj5 (neoplasm$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or dcis or ductal or infiltrat$ or intraductal$ or lobular or medullary)).mp.
  7. exp mammary neoplasms/
  8. (mammar$ adj5 (neoplasm$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or dcis or ductal or infiltrat$ or intraductal$ or lobular or medullary)).mp.
  9. or/1–2,5–8
  10. exp bone neoplasms/sc
  11. exp neoplasm metastasis/
  12. exp “bone and bones”/
  13. 11 and 12
  14. ((bone$ or skelet$ or osseous or osteo$) adj5 (second$ or metast$ or spread$ or advanc$ or termina$)).mp.
  15. 10 or 13 or 14
  16. exp hypercalcemia/
  17. exp Fractures, Bone/
  18. exp spinal cord compression/
  19. (hypercalc$ or fractur$ or break$ or compress$).mp.
  20. or/16–19
  21. exp neoplasms/
  22. 20 and 21
  23. 15 or 22
  24. 9 and 23
  25. ((radiotherap$ or radiat$) adj (therapy or treat$)).tw.
  26. exp Diphosphonates/
  27. (bisphosphonat$ or disphosphonat$).mp.
  28. (etidron$ or didron$ or difosfen$ or osteodidronel or osteum).mp.
  29. “disodium dihydrogen(1-hydroxyethylidene)diphosphonate”.mp.
  30. (pamidronate or APD or aredia).mp.
  31. “disodium 3-amino-1-hydroxypropylidenebisphosphonate”.tw.
  32. (clodronate or bonefos or loron or ascredar or lodronat$ or lytos or ostac or clastoban or clasteon or difosonal).tw.
  33. (ossiten or mebonat$ or tiludron$ or skelid or risedron$ or actonel).tw.
  34. (alendron$ or fosemax or adronat$ or alendros or dronal or neridron$ or AHDP).tw.
  35. (zoledron$ or zometa or ibandron$ or bondronat$ or incadron or olpadron$ or OPD or YM175 or YM529 or minodron$).tw.
  36. exp drug therapy/
  37. exp Antineoplastic Agents/
  38. ((chemotherapy or antineoplastic or anticancer) adj3 (agent$ or protocol$ or regimen$)).tw.
  39. exp Antineoplastic Combined Chemotherapy Protocols/
  40. (endocrin$ adj3 (treatment$ or therap$)).mp.
  41. exp Surgery/
  42. exp Surgical Procedures, Operative/
  43. exp Rehabilitation/
  44. exp Exercise Therapy/
  45. Acupuncture Therapy/ or Acupuncture Analgesia/ or Acupuncture/
  46. exp Relaxation/
  47. exp Massage/
  48. exp Analgesia/
  49. or/25–49
  50. 24 and 50

2. Health Economics Literature search details

Database nameNo of references foundFinish date of search
Medline9520/10/06
Premedline220/10/06
Embase9020/10/06
Cochrane Library (except NHSEED)-20/10/06
NHSEED2520/10/06
Cinahl1220/10/06
BNI820/10/06
Psychinfo620/10/06
EconLit2720/10/06
Web of Science (SCI & SSCI)6820/10/06
SIGLE020/10/06

Total References retrieved (after de-duplication): 242

3. Any further comments

Systematic reviews (2002+), RCT and Observational filters applied to basic search for the clinical review. SIGN Health Economics filter & SCHARR Quality of Life filter applied to basic search for the health economics review.

4. Update Search

For the update search, the same search criteria/filters were applied as initial search, date limit 2006–2008 and English language research chosen only.

Database nameNo of references foundNo of references retrievedFinish date of search
Medline2923929/04/08
Premedline (June 27, 2008)114 (already selected)30/06/08
Embase5303030/04/08
Cochrane Library (Issue 2, 2008)79929/04/08
Cinahl73830/04/08
BNI4030/04/08
Psychinfo5130/04/08
AMED9330/04/08
Web of Science (SCI & SSCI)4687230/04/08

Total References retrieved (after de-duplication): 90

Plus 0 additional references picked up from search alerts until 1st July 2008. Final Total: 90

Topic 19. The management of metastatic brain and meningeal disease (surgery, stereotactic radiotherapy, external beam radiotherapy, intrathecal chemotherapy, rehabilitation)

1. Literature search details

Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1966 -61816816/02/07
PremedlineFeb 15, 200713719/02/07
Embase1980 -149412820/02/07
Cochrane LibraryIssue 1, 2007792519/02/07
Cinahl1982 -19219/02/07
BNI1994 -0019/02/07
Psychinfo1806 -9019/02/07
AMED1985 -8019/02/07
SIGLE1980 - 200511019/02/07
Web of Science (SCI & SSCI)1970 -108115020/02/07
Biomed Central1997 -81220/02/07

Total References retrieved (after de-duplication): 305

Medline search strategy (This search strategy is adapted to each database)

  1. exp brain neoplasms/ or exp meningeal neoplasms/ or exp Spinal Neoplasms/
  2. ((brain or intracranial or cerebral) adj5 metastas#s).mp.
  3. metastatic brain.tw.
  4. (meninge$ adj5 (disease$ or carcinoma$ or tumour$ or tumor$ or spread or carcinosis or involvement or metast$)).ti,ab.
  5. ((brain or intracranial or cerebral or meninge$) adj5 (second$ or metast$ or spread$ or advanc$ or termina$)).mp.
  6. ((CNS or central nervous system$) adj5 (disease$ or carcinoma$ or tumour$ or tumor$ or spread or carcinosis or involvement or metast$)).ti,ab.
  7. or/1–6
  8. exp Neoplasm metastasis/
  9. exp Brain/
  10. exp Meninges/
  11. 9 or 10
  12. 8 and 11
  13. 7 or 12
  14. exp Breast Neoplasms/
  15. exp “Neoplasms, Ductal, Lobular, and Medullary”/
  16. Carcinoma, Intraductal, Noninfiltrating/
  17. Carcinoma, Lobular/
  18. Carcinoma, Medullary/
  19. exp mammary neoplasms/
  20. or/14–19
  21. exp Breast/
  22. breast.tw.
  23. 21 or 22
  24. (breast adj milk).tw.
  25. (breast adj tender$).tw.
  26. 24 or 25
  27. 23 not 26
  28. exp Neoplasms/
  29. 27 and 28
  30. (breast$ adj5 (neoplasm$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or leiomyosarcoma$ or dcis or duct$ or infiltrat$ or intraduct$ or lobul$ or medullary or tubular)).mp.
  31. (mammar$ adj5 (neoplasm$ or cancer$ or tumo?r$ or carcinoma$ or adenocarcinoma$ or sarcoma$ or leiomyosarcoma$ or dcis or duct$ or infiltrat$ or intraduct$ or lobul$ or medullary or tubular)).mp.
  32. Paget's Disease, Mammary/
  33. (paget$ and (breast$ or mammary or nipple$)).tw.
  34. or/30–33
  35. 20 or 34
  36. 13 and 35

2. Health Economics Literature search details

Database nameNo of references foundFinish date of search
Medline1320/02/07
Premedline020/02/07
Embase9720/02/07
Cochrane Library (except NHSEED)2720/02/07
NHSEED620/02/07
Cinahl420/02/07
BNI020/02/07
Psychinfo020/02/07
AMED120/02/07
EconLit020/02/07
Web of Science (SCI & SSCI)2020/02/07
SIGLE020/02/07

Total References retrieved (after de-duplication): 155

3. Any further comments

Systematic reviews (2002+), RCT’s and Observational filters applied to basic search for the clinical review. SIGN Health Economics filter & SCHARR Quality of Life filter applied to basic search for the health economics review.

4. Update Search

For the update search, the reviewer required only RCT’s and so the search was re-executed using a RCT filter, date limit 2006–2008 and English language only.

Database nameNo of references foundNo of references retrievedFinish date of search
Medline1482507/05/08
Premedline (June 27, 2008)131 (already selected) + 330/06/08
Embase1182409/05/08
Cochrane Library (Issue 2, 2008)24307/05/08
Cinahl12108/05/08
BNI0008/05/08
Psychinfo2008/05/08
AMED1008/05/08
Web of Science (SCI & SSCI)3513308/05/08

Total References retrieved (after de-duplication): 60

Plus 0 additional references picked up from search alerts until 1st July 2008. Final Total: 60

Copyright © 2009, National Collaborating Centre for Cancer.

No part of this publication may be reproduced, stored or transmitted in any form or by any means, without the prior written permission of the publisher or, in the case of reprographic reproduction, in accordance with the terms of licenses issued by the Copyright Licensing Agency in the UK. Enquiries concerning reproduction outside the terms stated here should be sent to the publisher at the UK address printed on this page.

The use of registered names, trademarks etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore for general use.

Bookshelf ID: NBK61865

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