Figure 4. Abl regulates lamellipodial and filopodial formation via distinct mechanisms.

Figure 4

Abl regulates lamellipodial and filopodial formation via distinct mechanisms. A) Promotion of lamellipodial formation by Abl. Integrin-mediated adhesion to the extracellular matrix promotes the assembly of a protein complex containing Abl and Abi-1 and WAVE2.89 This complex localizes to the lamellipodium periphery, where it activates the Arp2/3 complex to nucleate new actin filaments. B) Promotion of filopodial formation by Abl. Following activation by integrin-mediated adhesion, Abl phosphorylates Dok-1, allowing complex formation with the Nck-1 adaptor protein and N-WASp.36 This protein complex activates actin filament nucleation and the resulting actin filaments become bundled and convergently extended into a filopodium. Abl localizes to the filopodial tips where it may regulate actin filament elongation.36

From: Regulation of Cytoskeletal Dynamics and Cell Morphogenesis by Abl Family Kinases

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