Table 4Summary of head-to-head trials with the outcome of ≥50% reduction in pain

Author, YearNStudy designDuration of trialOutcomeQuality rating
Gabapentin vs. amitriptyline or nortriptyline
 Gilron, 200947Crossover18 weeksRR 0.86 (0.65 to 1.11)Fair
 Dallocchio, 200025Parallel12 weeksRR 1.13 (0.76 to 1.68)Fair
 Morello, 199925Crossover13 weeksRR 0.79 (0.45 to 1.38)Fair
 Chandra, 200676Parallel9 weeksRR 0.78 (0.32 to 1.87)Fair
Gabapentin Pooled173RR 0.90 (0.74 to 1.10)
Pregabalin vs. amitriptyline
 Pfizer 1008-040, 2007175Parallel10 weeksRR 0.89 (0.63 to 1.25)Fair
 Bansal, 200975Crossover14 weeksRR 1.35 (0.88 to 2.07)Fair
Pregabalin Pooled250RR 1.07 (0.71 to 1.62)
Lamotrigine vs. amitriptyline
 Jose, 200775Crossover14 weeksRR 1.39 (0.87 to 2.23)Fair
 All Trials Pooled498RR 1.00 (0.84 to 1.18)

Abbreviation: RR, relative risk.

From: Results

Cover of Drug Class Review: Neuropathic Pain
Drug Class Review: Neuropathic Pain: Final Update 1 Report [Internet].
Selph S, Carson S, Fu R, et al.
Portland (OR): Oregon Health & Science University; 2011 Jun.
Copyright © 2011 by Oregon Health & Science University.

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