Figure 5. Mitotic neurons.

Figure 5Mitotic neurons

TD neurons derived from the P19 embryo carcinoma cell line by retinoic acid treatment were infected with adenovirus to express E1A. The upper panel shows a phase contrast view. The lower panel shows an immunofluorescence for 5-bromo-2'-deoxyuridine, demonstrating DNA synthesis. The two neurons marked by triangles are rounded and display metaphase-like chromosomal arrangement. The metaphase plate on the left is perpendicular to the plane of the photograph, while that on the right is parallel. Large, flat, non-neuronal cells are present.

From: Cell Cycle Reactivation in Skeletal Muscle and Other Terminally Differentiated Cells

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