Figure 12. Cardiomyocyte contractility is maintained under chemical hypoxia by ATP-vesicles.

Figure 12

Cardiomyocyte contractility is maintained under chemical hypoxia by ATP-vesicles. The cells were stimulated with 0.5-4 Hz, 8-volt electric stimulator (MyoPacer™) and contractile velocity and duration of contraction were recorded after a 30-minute incubation in KCN (5 mM). Both diastolic and systolic contraction velocities were significantly increased by the presence of ATP-vesicles. In contrast, neither vesicles + non-encapsulated ATP, ATP only, or M199 media could maintain the same velocity of contraction compared to the ATP-vesicles group. *Significantly different from vesicles + ATP, ATP only, or M199 as measured by ANOVA (p < 0.05), N = 6.

From: Metabolic Management

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