Figure 4. Overexpression of ECE-1a or ECE-1b in CHO cells reduces extracellular Αβ concentration.

Figure 4

Overexpression of ECE-1a or ECE-1b in CHO cells reduces extracellular Αβ concentration. Αβ40 (A) and Αβ42 (B) concentration in the conditioned media of stable ECE-1a and ECE-1b transfected CHO cell lines was determined by sandwich ELISA following a 24 hour incubation ± 100 μM phosphoramidon. Data are plotted as mean ± SE of triplicate wells. Reprinted with permission from: Eckman EA, Reed DK, Eckman CB. J Biol Chem 2001; 276(27):245408, 2001 American Society for Biochemistry and Molecular Biology.

From: Αβ Degradation by Endothelin-Converting Enzymes

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