Figure 1. Role of CRH on implantation and immunotolerance of the fetus: CRH, produced locally by decidual and extravillous trophoblast cells, acts in an autocrine/paracrine fashion, through CRH-R1, to stimulate FasL expression and induce apoptosis of activated maternal T lymphocytes expressing Fas.

Figure 1

Role of CRH on implantation and immunotolerance of the fetus: CRH, produced locally by decidual and extravillous trophoblast cells, acts in an autocrine/paracrine fashion, through CRH-R1, to stimulate FasL expression and induce apoptosis of activated maternal T lymphocytes expressing Fas. Abbreviations: CRH: corticotropin-releasing hormone; CRH-R1: CRH receptor type 1; DC: decidual cell; EVT: extravillous trophoblast; Fas: Fas receptor; FasL: Fas ligand; T: T lymphocyte.

From: The Role of Corticotropin-Releasing Hormone (CRH) on Implantation and Immunotolerance of the Fetus

Cover of Madame Curie Bioscience Database
Madame Curie Bioscience Database [Internet].
Austin (TX): Landes Bioscience; 2000-2013.
Copyright © 2000-2013, Landes Bioscience.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.