Figure 6. Facial development relies on the Hox-negative NC.

Figure 6

Facial development relies on the Hox-negative NC. A) Removal of the Hox-negative NC in early chick neurula (dotted lines) results in absence of facial structures and exencephaly in E7 operated embryos (B). C) Replacement of the anterior Hox-negative NC by an exogenous fragment of Hox-positive NC severely hampers head morphogenesis at E7 (D). E) Following removal of the anterior Hox-negative NC (as in A), the implantation of only a fragment from either di-, mes- or anterior rhombencephalic level (i.e., Hox-negative NC) restores normal development of the face and forebrain at E7 (F).

From: The Contribution of the Neural Crest to the Vertebrate Body

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