Advanced telencephalic pathology in the insular and subgenual mesocortex of an IPD case. (α-synuclein immunoreactions without counter-staining, PEG 100 μm sections). Note the severe involvement of the agranular (a) and dysgranular (b) portions of the insular mesocortex and of the agranular (c) and dysgranular (d) portions of the subgenual mesocortex. These areas are characterized by numerous granular and filiform LNs that fill layers II and III. Calibration bar in (d) is also valid for (a-c).
From: Idiopathic Parkinson's Disease: Staging an α-Synucleinopathy with a Predictable Pathoanatomy
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