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Bookshelf ID: NBK606317PMID: 39190736
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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 1276027-63-4
Drug Levels and Effects
Summary of Use during Lactation
No information is available on the clinical use of sebelipase alfa during breastfeeding. Because it is a large protein molecule with a molecular weight of about 55,000 Da, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. If sebelipase alfa is required by the mother, it is not a reason to discontinue breastfeeding. Until more data are available, sebelipase alfa should be used with infant careful monitoring during breastfeeding.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Substance Identification
Substance Name
Sebelipase Alfa
CAS Registry Number
1276027-63-4
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Breastfeeding Links
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- Clinical outcome of a patient with lysosomal acid lipase deficiency and first results after initiation of treatment with Sebelipase alfa: A case report.[Mol Genet Metab Rep. 2019]Clinical outcome of a patient with lysosomal acid lipase deficiency and first results after initiation of treatment with Sebelipase alfa: A case report.Soll D, Spira D, Hollstein T, Haberbosch L, Demuth I, Steinhagen-Thiessen E, Bobbert T, Spranger J, Kassner U. Mol Genet Metab Rep. 2019 Sep; 20:100479. Epub 2019 Jun 18.
- Review Sebelipase alfa: enzymatic replacement treatment for lysosomal acid lipase deficiency.[Drugs Today (Barc). 2016]Review Sebelipase alfa: enzymatic replacement treatment for lysosomal acid lipase deficiency.Paton DM. Drugs Today (Barc). 2016 May; 52(5):287-93.
- Hepatic cholesteryl ester accumulation in lysosomal acid lipase deficiency: non-invasive identification and treatment monitoring by magnetic resonance.[J Hepatol. 2013]Hepatic cholesteryl ester accumulation in lysosomal acid lipase deficiency: non-invasive identification and treatment monitoring by magnetic resonance.Thelwall PE, Smith FE, Leavitt MC, Canty D, Hu W, Hollingsworth KG, Thoma C, Trenell MI, Taylor R, Rutkowski JV, et al. J Hepatol. 2013 Sep; 59(3):543-9. Epub 2013 Apr 25.
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