Figure 1. Lysosomal degradation of proteins.

Figure 1

Lysosomal degradation of proteins. Proteins are incorporated into lysosomes by various pathways (see fig.2). They are degraded to amino acids in the lysosomal lumen by several lysosomal proteases (generally called cathepsins), which are more active at acid pH. The acid pH, which is maintained by an ATP-driven proton pump in the lysosomal membrane, may also affect the conformation of proteins and aid in their breakdown. Amino acids exit from the lysosome to the cytosol for further metabolism.

From: Chaperone-Mediated Autophagy

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