Table 1Structures of WD and Kelch repeat proteins

ProteinRefSpeciesPDB##Repeats/ #BladesClosure Mechanism
WD:
Aip1p27Budding yeast1p1610/14N-term**
ARPC1*36Cow1k8k7/7N-term
Bub3p26,28Budding yeast1u4c, 1yfq4/7N-term
β-TrCP*65Human1p227/7N-term
Cdc4p*29Budding yeast1nex8/8N-term
Coronin 1A66Mouse2aq55/7N-term
Gβ*11,12,15Cow, Rat1g0t, 1gp27/7N-term
Groucho1*67Human1gxr5/7N-term
LIS1*35Mouse1vyh7/7N-term
Sif2p68Budding yeast1r5m8/8N-term
Ski8p9,69Budding yeast1s4u, 1sq95/7N-term
Tup1p70Budding yeast1erj6/7N-term
Kelch:
galactose oxidase10Fungal (D. dendroides)1gof7/7N-term
Keap1*13Human1× 2j6/6C-term
Keap1*14Mouse1u6d6/6C-term

*The structure of the protein has been determined as part of a protein complex or with a peptide ligand bound. #Repeats/#Blades indicates the number of sequence repeats identified by sequence analysis, followed by the number of blades (and therefore, additional poorly-conserved sequence repeats) identified after structural determination. See text for information on closure mechanisms.

**Aip1p is organized into two 7-bladed propellers; the N-terminal strand closes the C-terminal propeller and then proceeds to blade 1 of the first propeller. There is no similar closure of the first propeller.27

From: Phylogenetic, Structural and Functional Relationships between WD-and Kelch-Repeat Proteins

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