Figure 2. Alternative structures of the pheST leader mRNA.

Figure 2

Alternative structures of the pheST leader mRNA. The initiation codon, the five phenylalanine codons of the leader peptide and the U stretch of the terminator are written out, the stop codon is boxed. Important regions 1, 2, 3, and 4 are indicated. A) mRNA structure in the absence of translation initiation, formation of the terminator 3/4 provokes premature termination. B) A ribosome stalled at the first or second Phe codon does not hinder the formation of the anti-antiterminator 1/2, termination occurs. C) A ribosome stalling at the last two Phe codons sequesters region 1 which favors formation of the antiterminator 2/3, readthrough occurs. D) Efficient translation of all Phe codons prevents formation of the antiterminator causing premature termination. Dashes indicate Watson-Crick base pairs.

From: Regulation of the Expression of Aminoacyl-tRNA Synthetases and Translation Factors

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