Figure 5. Co-expression of p193 and T-Ag results in cytoplasmic sequestration of both proteins.

Figure 5

Co-expression of p193 and T-Ag results in cytoplasmic sequestration of both proteins. NIH-3T3 cells were transfected with CMV-193myc, with CMV-T-Ag (an expression construct encoding T-Ag), or co-transfected with both CMV-193myc and CMV-T-Ag. The subcellular locations of p193 and T-Ag were then determined by immune cytology. In the singly-transfected cells, p193 is localized in the cytoplasm (top left panel) and T-Ag is localized in the nucleus (top right panel). In a cotransfected cell, both p193 and T-Ag are localized in the cytoplasm (the same cell is depicted in the lower panels; p193 immune reactivity is shown on the left, T-Ag immune reactivity is shown on the right). [Adapted from ref. 18]

From: Regulation of Cardiomyocyte Proliferation and Apoptosis

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