Figure 3. Activation of genes by BRCA1 relevant to the cell cycle.

Figure 3

Activation of genes by BRCA1 relevant to the cell cycle. BRCA1 has been shown to control the expression levels of four genes—p21WAF1, Gadd45, Cyclin B1, and EGR1—that have implications on checkpoint activation. The p21WAF1 and EGR1 genes are involved in G1 phase of the cell cycle and may effect the onset of a G1 block prior to DNA replication in the face of DNA damage. The induction of Gadd45 and repression of Cyclin B1 may represent an attempt by BRCA1 to halt progression towards mitosis.

From: Functional Interactions Between BRCA1 and the Cell Cycle

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