Figure 4. Targeted expression of PARP in the developing eye causes rough-eye phenotype.

Figure 4

Targeted expression of PARP in the developing eye causes rough-eye phenotype. A-C, scanning electron micrographs of adult eyes from wild-type (A), 2 x GMR-PARP (B), and 4 x GMR-PARP (C). D-F, tangential sections of compound eyes from wild-type (D), 2 x GMR-PARP (E), and 4 x GMR-PARP (F). The red line indicates the equator. The right-hand panels of D-F show a schematic drawing of the same area. Numbers 1-7 schematically indicate the arrangement of rhabdomeres in seven photoreceptors in an ommatidium. A rectangular pattern of rhabdomeres is shown in red. G-I, apical surface of cobalt sulfide-stained midpupal retinas from wild-type (G), 2 x GMR-PARP (H), and 4 x GMR-PARP (I). c indicates cone cells; the numbers 1, 2, and 3 indicate primary, secondary, and tertiary pigment cells, respectively; and b indicates bristle cell. (Reprinted from J Biol Chem 277:6696-6702, 2002; with permission)

From: Roles of Poly(ADP-Ribose) Metabolism in the Regulation of Centrosome Duplication and in the Maintenance of Neuronal Integrity

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