Figure 1. Predicted secondary structures of ABC transporters.

Figure 1

Predicted secondary structures of ABC transporters. Three classes of transporters are presented here each contains multiple transmembrane domain (TMD)(cylinders) and intracellularly located nucleotide-binding domain (NBD). Pgp, MRP1 and BCRP have 12, 17, and 6 TMD, respectively. MDR1/Pgp and MRP1 have two NBD whereas BCRP has only one. N and C refer to the amino- and carboxyl-terminal ends of the molecules, respectively.

From: Roles of Multidrug Resistance Genes in Breast Cancer Chemoresistance

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