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Varki A, Cummings RD, Esko JD, et al., editors. Essentials of Glycobiology [Internet]. 4th edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2022. doi: 10.1101/glycobiology.4e.44

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Essentials of Glycobiology [Internet]. 4th edition.

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FIGURE 44.2.. Degradation of hyaluronan and heparan sulfate (HS).

FIGURE 44.2.

Degradation of hyaluronan and heparan sulfate (HS). (Left) Hyaluronidase (an endoglycosidase) cleaves large chains into smaller fragments, each of which is then sequentially degraded from the nonreducing end. (Right) Degradation of HS. An endo-β-glucuronidase first cleaves large chains into smaller fragments, and each monosaccharide is then removed from the nonreducing end as described in the text. N- and O-sulfate groups must first be removed before exoglycosidases can act. An unusual feature of HS degradation is that this process also involves a synthetic step. After removal of the N-sulfate residue on GlcNSO4, the nonacetylated glucosamine must first be N-acetylated using acetyl-CoA before α-N-acetylglucosaminidase can cleave this residue.

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From: Chapter 44, Genetic Disorders of Glycan Degradation

Copyright © 2022 The Consortium of Glycobiology Editors, La Jolla, California; published by Cold Spring Harbor Laboratory Press; doi:10.1101/glycobiology.4e.44. All rights reserved.

The content of this book is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 Unported license. To view the terms and conditions of this license, visit https://creativecommons.org/licenses/by-nc-nd/4.0/

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